Asymmetric pendrin homodimer reveals its molecular mechanism …
2023年5月25日 · Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder …
Pendrin - Wikipedia
Pendrin is the protein which is mutated in Pendred syndrome, which is an autosomal recessive disorder characterized by sensorineural hearing loss, goiter and a partial organification …
Nature Communications｜陈振国/孙蕾合作团队报道Pendrin蛋白 …
2023年5月30日 · 研究团队通过冷冻电镜解析了pendrin在单一阴离子缓冲条件和双阴离子缓冲条件中和不同阴离子结合的多种构象的高分辨率结构（最高分辨率达3.2 Å），并通过离子交换荧 …
Mechanism of anion exchange and small-molecule inhibition of pendrin
2024年1月6日 · Pendrin (SLC26A4) is an anion exchanger that mediates bicarbonate (HCO 3−) exchange for chloride (Cl −) and is crucial for maintaining pH and salt homeostasis in the …
Pendrin: linking acid base to blood pressure | Pflügers Archiv ...
2023年12月19日 · Pendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which is mutated in human patients affected by Pendred syndrome, an autosomal recessive …
Pendrin - an overview | ScienceDirect Topics
Pendrin is a 73 kDa membrane protein comprised of 780 amino acids (Scott and Karniski, 2000; Royaux et al., 2000). It is predicted to have 12 putative transmembrane domains with both the …
Pendrin, an anion exchanger on lung epithelial cells, could be a …
2016年2月15日 · Pendrin (slc26a4) overexpression caused increased mucus production and elevated production of the neutrophil-attracting chemokines CXCL1 and CXCL2 [10,11]. …
Molecular and functional characterization of human pendrin …
Pendrin (SLC26A4, PDS) is an electroneutral anion exchanger transporting I(-), Cl(-), HCO(3)(-), OH(-), SCN(-) and formate. In the thyroid, pendrin is expressed at the apical membrane of the …
Pendrin蛋白在甲状腺疾病中的研究进展 - 百度文库
Pendrin蛋白在甲状腺疾病中的研究进展-碘是甲状腺激素合成必不可少的原料,碘从血液中被转运到甲状腺滤泡中是由转运蛋白介导完成,目前研究表明主要有2个步骤：碘先从血液中转运到甲状 …
【doc】Pendrin蛋白研究进展 - 豆丁网
2013年12月3日 · Pendrin蛋白是.PDS(pendredsyndrome,临床上相对 常见的常染色体隐性遗传性疾病,临床主要特点为先天 性神经性耳聋和甲状腺肿大)基因的表达产物.Coucke