2020年3月19日 · Many endogenous peptides activate G protein-coupled receptors (GPCRs) — nearly 50 GPCR peptide drugs have been approved to date, most of them for metabolic disease or oncology, and more than...

The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as inflammatory responses including cell adhesion, directed migration, granule release and ...

Signaling peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins. An example is the tropomyosin receptor kinase B (TrkB), which is bound and activated by the neurotrophic protein brain-derived neurotrophic factor (BDNF).

2024年9月5日 · Peptides are integral to cell signaling, functioning as ligands that bind to receptors on target cells and trigger a cascade of intracellular responses. These signaling peptides interact with receptors such as G-protein-coupled receptors, GPCRs, and receptor tyrosine kinases, RTKs, to mediate essent

Many biological functions of peptides are mediated through G protein-coupled receptors (GPCRs). Upon ligand binding, GPCRs undergo conformational changes that facilitate the binding and activation of multiple effectors. GPCRs regulate nearly all physiological processes and are a favorite pharmacological target.

A peptide receptor is a specific target in the body that can be bound by designed peptide sequences for drug delivery or therapy, especially in the context of cancer treatment.

Virtually all neuropeptides mediate their effects by activating G-proteincoupled receptors. The study of these metabotropic peptide receptors in the brain has been difficult because few specific agonists and antagonists are known.

Peptide–receptor interactions play critical roles in a wide variety of physiological processes. Methods to link bioactive peptides covalently to unmodified receptors on the surfaces of living cells are valuable for studying receptor signaling, dynamics, and trafficking and for identifying novel peptide–receptor interactions.

2017年8月18日 · In this review, we analyze the 21 experimentally determined three-dimensional structures of the known peptide-binding GPCRs in relation to the endogenous peptides and drug molecules that modulate their cell signaling processes.

2002年11月1日 · Today, a robust strategy has been developed for the design of peptides as drugs, drug candidates and biological tools. This strategy includes structural, conformational, dynamic and topographical...