Activation of the integrated stress response by inhibitors of its ...
2023年9月8日 · Reconstitution of ISR activation with recombinant proteins demonstrates that PERK and PKR inhibitors directly activate dimeric GCN2, following a Gaussian activation …
Nature：线粒体可释放求救信号到细胞质中 - 知乎
eif2α磷酸化由四种激酶介导，即gcn2、perk、pkr和 hri 每个磷酸化的eif2α对不同的应激源有反应。氨基酸的减少刺激了绿色通道2；perk对一种叫做内质网的组织中未折叠蛋白质的存在作出 …
PERK and GCN2 Contribute to eIF2α Phosphorylation and Cell …
Our results demonstrate that PERK and GCN2 function to cooperatively regulate eIF2α phosphorylation and cyclin D1 translation after UPR activation. Integral membrane proteins …
Integrated stress response of vertebrates is regulated by four …
2016年9月16日 · Four eIF2α kinases, namely heme-regulated inhibitor (HRI), protein kinase R (PKR), PKR-like endoplasmic reticulum kinase, (PERK) and general control non-depressible 2 …
Reciprocal regulation between GCN2 (eIF2AK4) and PERK
2020年9月15日 · To test the conjecture that GCN2 compensates for PERK inactivation and to explore further the mechanism for PERK regulation, we investigated the effects of the …
『珍藏版』Science综述 | 整合应激反应——从机制到复杂疾病 - 知乎
整合应激反应 （integrated stress response ISR）是蛋白质稳态失调时诱发的信号中心调控网络，主要以控制蛋白质合成速率来实现。 2020年4月24日，美国贝勒医学院的 Mauro Costa …
Reciprocal regulation between GCN2 (eIF2AK4) and PERK …
2020年9月9日 · To explore the potential mechanisms involved, we performed time-course drug treatment experiments on the parental MCF-7 and drug resistant MCF-7Epi R and MCF-7Tax …
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell …
Exposure of cells to endoplasmic reticulum (ER) stress leads to activation of PKR-like ER kinase (PERK), eukaryotic translation initiation factor 2alpha (eIF2alpha) phosphorylation, repression …
eIF2α kinases PERK and GCN2 act on FOXO to potentiate FOXO activity
2018年7月24日 · PERK and GCN2 are eIF2α kinases known to mediate the effects of ER stress and respond to an array of diverse stress stimuli. Previously, we reported that ER stress …
The GCN2 / eIF2αK stress kinase regulates PP1 to ensure mitotic …
2023年6月9日 · PERK and GCN2 share considerable functional redundancy in the integrated stress response and their functions can overlap (Hamanaka et al, 2005; Lehman et al, 2015). …