2024年12月25日 · PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2) is a Protein Coding gene. Diseases associated with PFKFB2 include Breast Lipoma and Maturity-Onset Diabetes Of The Young, Type 2. Among its related pathways are Glycolysis (REACTOME) and fructose 2,6-bisphosphate synthesis.

Broad expression in thyroid (RPKM 25.6), duodenum (RPKM 11.7) and 19 other tissues. 该基因编码的蛋白质参与果糖-2,6-二磷酸的合成和降解，果糖是一种控制真核生物糖酵解的调节分子。 编码的蛋白质具有催化 2,6-二磷酸果糖合成的 6-磷酸果糖-2-激酶活性和催化 2,6-二磷酸果糖降解的 2,6-二磷酸果糖酶活性。 这种蛋白质调节心脏中的果糖 2,6-二磷酸水平，而由不同基因编码的相关酶调节肝脏和肌肉中的果糖 2,6-二磷酸水平。 这种酶作为同型二聚体发挥作用。 已发现该基因的 …

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene. [5] The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in …

2023年2月16日 · We found that efferocytosis promotes a transient increase in macrophage glycolysis that is dependent on rapid activation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2...

We found that efferocytosis promotes a transient increase in macrophage glycolysis that is dependent on rapid activation of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2), which distinguishes this process from glycolysis in …

2025年2月8日 · Gene ID: 18640, updated on 8-Feb-2025. Enables 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including carbohydrate catabolic process; fructose 2,6-bisphosphate metabolic process; and positive regulation of insulin secretion.

PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells. This study aims to characterise the expression and phosphorylation of isozymes of the key glycolytic regulatory protein, 6-phosphofructokinase-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2), in urinary exosomes of subjects with pre-eclampsia .

PFKFB1 encodes the isoenzyme identified in fetal tissue and the liver; PFKFB2 encodes a protein expressed mainly in the heart and kidney; the product of PFKFB3 occurs in adipose tissue, the brain, and frequently in cancer cells; and PFKFB4 is almost exclusively significantly expressed in testes and tumor cells .

使用皮肤细胞转化JB6模型，我们证明了UCP2过表达激活了磷酸果糖激酶2 /果糖-2,6-双磷酸酶2（PFKFB2），这是糖酵解的关键调节因子。 结合起来，PFKFB2表达的上调与果糖2，6-双磷酸（Fru-2,6-P2）水平，6-磷酸果糖-1-激酶（PFK-1）活性，葡萄糖摄取和乳酸生成相关。 抑制PFKFB2表达可抑制UCP2介导的皮肤细胞转化，减少细胞增殖并增强线粒体呼吸，同时抑制需氧糖酵解。 AKT信号通路在UCP2过表达的细胞中被激活。 此外，激活的AKT信号有助于PFKFB2 …

2024年1月26日 · PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells. A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.