PFKFB4 Gene - GeneCards | F264 Protein | F264 Antibody
2024年12月25日 · PFKFB4 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4) is a Protein Coding gene. Diseases associated with PFKFB4 include Pancreatic Cancer. Among …
PFKFB4 - Wikipedia
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 also known as PFKFB4 is an enzyme which in humans is encoded by the PFKFB4 gene. [5][6]
6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶 4（PFKFB4）基因 | MCE
该基因编码的蛋白质是四种双功能激酶/磷酸酶之一，可调节糖酵解副产物果糖-2,6-二磷酸 (F2,6BP) 的浓度。 编码的蛋白质在癌细胞中高表达，并由缺氧诱导。 这种蛋白质对于癌细胞在 …
PFKFB3 和 PFKFB4 在癌症中的作用：遗传基础、对疾病发生/进展 …
Four isozymes of PFKFB (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) have been identified. Alterations in the levels of all PFK-2/FBPase-2 isozymes have been reported in different …
Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on …
The PFKFB4 protein is a bifunctional enzyme that increases the cellular level of F-2,6-BP (and thus glycolytic flux) or decreases F-2,6-BP concentration, which results in the redirection of …
Metabolic enzyme PFKFB4 activates transcriptional coactivator …
PFKFB4, a regulatory enzyme that synthesizes a potent stimulator of glycolysis 2, is found to be a robust stimulator of SRC-3 that coregulates oestrogen receptor. PFKFB4 phosphorylates SRC …
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PFKFB4 Drives the Oncogenicity in TP53-Mutated Hepatocellular Carcinoma in a Phosphatase-Dependent Manner. PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance …
Metabolic enzyme PFKFB4 activates transcriptional coactivator
2018年4月3日 · Here we show that the metabolic enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) regulates transcriptional reprogramming by activating the …
重大突破，南京医科大学发现肺癌治疗新靶点 - 澎湃新闻
2023年8月1日 · pfkfb4可以促进乳酸和atp的产生，维持癌干细胞样细胞的存活。 此外，PFKFB4可以磷酸化SRC，促进乳腺癌和LUAD的进展。 研究人员发现，THOC3调节pfkfb4mrna的核胞 …
PFKFB4的生物学作用及其在泌尿系统肿瘤中的研究进展
2022年10月24日 · 研究表明，PFKFB4在多种实体肿瘤中高表达，且被认为与肿瘤预后不良有关。 本文就PFKFB4的生物学特征、在肿瘤进展中的作用机制以及在常见泌尿系统肿瘤中的研究进 …