Inhibition of the prostaglandin-degrading enzyme 15-PGDH ... - Science
2015年6月12日 · In this study, we take the converse approach: We examine the role of a prostaglandin-degrading enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH), as a negative regulator of tissue repair, and we explore whether inhibition of this enzyme can potentiate tissue regeneration in mouse models.
Small molecule inhibitors of 15-PGDH exploit a physiologic
2023年2月11日 · 15-prostaglandin dehydrogenase (15-PGDH) is a negative regulator of tissue stem cells that acts via enzymatic activity of oxidizing and degrading PGE2, and related...
Nature丨打破惯有认知，代谢酶PHGDH异质性或决定癌细胞转移能 …
该研究发现代谢酶磷酸甘油酸脱氢酶（phosphoglycerate dehydrogenase, PHGDH）的异质性（可变）表达是肿瘤侵袭性的标志。 PHGDH 是丝氨酸合成通路中的关键酶，编码这种酶的基因在三阴性乳腺癌（TNBCs）、黑色素瘤等肿瘤中高表达。 研究人员发现，异质性/低表达PHGDH浸润性乳腺导管癌患者的中位无进展生存期和无转移生存期较同质性表达PHGDH患者降低了约3倍。 在TNBC患者中，PHGDH蛋白低表达与细胞增殖标志物Ki67反相关，但与 上皮-间质转化 …
Recent advances in studies of 15-PGDH as a key enzyme for the ...
15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2α) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also known as PGT, OATP2A1, PHOAR2, or SLC21A2).
Inhibition of prostaglandin-degrading enzyme 15-PGDH
2021年1月29日 · We identifed increased amounts of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the prostaglandin E 2 (PGE 2)-degrading enzyme, as a hallmark of aged tissues, including skeletal muscle.
15-PGDH作为降解前列腺素关键酶的研究进展 ... - X-MOL
15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2α) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also known as PGT, OATP2A1, PHOAR2, or SLC21A2).
Recent advances in studies of 15-PGDH as a key enzyme for the ...
2021年12月1日 · 15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; mainly PGE2, PGD2, and PGF2α) in a process mediated by solute carrier organic anion transport protein family member 2A1 (SLCO2A1; also …
Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis …
2020年7月15日 · Here we evaluated pulmonary 15-PGDH expression and activity and tested whether pharmacologic 15-PGDH inhibition (PGDHi) is protective in a mouse model of bleomycin-induced pulmonary fibrosis (PF).
15-羟前列腺素脱氢酶（15-PGDH）可防止脂多糖（LPS）诱导的急 …
NAD +依赖性15-羟基前列腺素脱氢酶（15-PGDH）催化前列腺素E2（PGE2）的15（S）-羟基氧化，将促炎性PGE2转变为消炎性15-酮-PGE2（an过氧化物酶体增殖物激活受体-γ [PPAR-γ]的内源性配体。 为了评估15-PGDH / 15-酮-PGE2级联在肝脏炎症和组织损伤中的重要性，我们生成了在肝脏中靶向表达15-PGDH的转基因小鼠（15-PGDH Tg），并对动物进行了脂多糖（ LPS）/半乳糖胺（GalN）诱导的急性肝炎症和损伤。 与野生型小鼠相比，15-PGDH Tg小鼠的丙氨酸氨 …
抑制前列腺素降解酶 15-PGDH 可增强组织再生,Science - X-MOL
2015年6月11日 · 前列腺素 PGE2 是一种脂质信号分子，支持多种类型的组织干细胞的扩增，是促进体内组织再生的候选治疗靶点。 迄今为止，治疗干预主要集中在靶向两种 PGE2 生物合成酶，环氧合酶-1 和环氧合酶-2（COX-1 和 COX-2），目的是减少 PGE2 的产生。 在这项研究中，我们采用了相反的方法：我们检查了前列腺素降解酶的作用，15-羟基前列腺素脱氢酶 (15-PGDH) 作为组织修复的负调节因子，我们探讨了抑制这种酶是否可以增强小鼠模型中的组织再生。 基 …