Inhibition of the prostaglandin-degrading enzyme 15-PGDH ... - Science
Jun 12, 2015 · In this study, we take the converse approach: We examine the role of a prostaglandin-degrading enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH), as a …
Inhibition of prostaglandin-degrading enzyme 15-PGDH ... - Science
Restoring PGE2 concentrations by inhibiting 15-PGDH in older mice improved muscle function. Decreased activity of 15-PGDH in older animals had beneficial effects that included decreased …
重大进展！抑制15-PGDH蛋白可让年老小鼠的肌肉返老还童 - 知乎
PGE2水平受15-PGDH的调控，后者可降解PGE2。 这些研究人员使用高灵敏度的 质谱技术 （一种区分密切相关分子的方法）确定，与年轻小鼠相比，年老小鼠肌肉中的15-PGDH水平升 …
Small molecule inhibitors of 15-PGDH exploit a physiologic
Feb 11, 2023 · 15-prostaglandin dehydrogenase (15-PGDH) is a negative regulator of tissue stem cells that acts via enzymatic activity of oxidizing and degrading PGE2, and related...
Nature丨打破惯有认知，代谢酶PHGDH异质性或决定癌细胞转移能 …
该研究发现代谢酶磷酸甘油酸脱氢酶（phosphoglycerate dehydrogenase, PHGDH）的异质性（可变）表达是肿瘤侵袭性的标志。 PHGDH 是丝氨酸合成通路中的关键酶，编码这种酶的基因在 …
Inhibition of prostaglandin-degrading enzyme 15-PGDH
Jan 29, 2021 · We identifed increased amounts of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the prostaglandin E 2 (PGE 2)-degrading enzyme, as a hallmark of aged tissues, …
15-PGDH作为降解前列腺素关键酶的研究进展 ... - X-MOL
15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; …
Inhibition of Prostaglandin Degrading Enzyme 15-PGDH …
Here we identify elevated 15-PGDH, the Prostaglandin E2 (PGE2) degrading enzyme, as a hallmark of aged tissues, including skeletal muscle. The resulting reduction in PGE2 signaling …
Recent advances in studies of 15-PGDH as a key enzyme for the ...
15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; …
Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis …
Jul 15, 2020 · Here we evaluated pulmonary 15-PGDH expression and activity and tested whether pharmacologic 15-PGDH inhibition (PGDHi) is protective in a mouse model of …