Shematic mechanism of intrarenal vasodilation by the 15-hydoxyprostaglandin dehydrogenase (15-PGDH) inhibitor (PGDH-i) in ischemic acute kidney injury. 15-PGDH inhibitor pretreatment …

2021年1月29日 · We identifed increased amounts of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the prostaglandin E 2 (PGE 2)-degrading enzyme, as a hallmark of aged tissues, …

2023年2月11日 · 15-prostaglandin dehydrogenase (15-PGDH) is a negative regulator of tissue stem cells that acts via enzymatic activity of oxidizing and degrading PGE2, and...

2020年12月10日 · Restoring PGE2 concentrations by inhibiting 15-PGDH in older mice improved muscle function. Decreased activity of 15-PGDH in older animals had beneficial effects that …

2021年12月1日 · 15-PGDH is a key enzyme in degrading PGs, including PGE 2, by catalyzing the transformation of the 15-hydroxyl group of PGE 2 to 15-keto-PGE 2, resulting in biologically …

The NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E 2 (PGE 2), converting the pro …

In this study, we investigated the effect of PGE 2 on its own inactivating enzyme, 15-PGDH. PGE 2 repressed 15-PGDH through a complex mechanism involving down-regulation of the cell …

We identifed increased amounts of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the prostaglandin E2 (PGE2)–degrading enzyme, as a hallmark of aged tissues, including skeletal …

2002年2月1日 · By generating mice deficient in 15-hydroxy-prostaglandin dehydrogenase (PGDH) (Fig. 1 a), we demonstrate that this is the primary enzyme regulating PGE 2 metabolism in vivo.

2023年8月1日 · Recent studies have shown that administration of SW033291, a newly identified small molecule inhibitor of 15-PGDH, exerts protective effects against various …