Prostaglandin J2 (PGJ2) 是前列腺素 D2 (PGD2; HY-101988) 的一种内源性代谢物，是一种有效的 PGD2 受体 (DP) 激动剂，对 hDP 和 hCRTH2 的 K 分别为 0.9 nM 和 6.6 nM。 Prostaglandin J2 刺激细胞内环 AMP 的产生，EC 50 值为 1.2 nM。 Prostaglandin J2 诱导氧化应激和神经细胞凋亡。

Feb 1, 2005 · In this review, we summarize the current understanding of 15d-PGJ 2 synthesis, biology and main effects both in molecular physiology and pathological states.

In particular, 15d-PGJ2 is recognized as the endogenous ligand for the intranuclear receptor PPARgamma. This property is responsible for many of the 15d-PGJ2 anti-inflammatory functions. In this review, we summarize the current understanding of 15d-PGJ2 synthesis, biology and main effects both in molecular physiology and pathological states.

Prostaglandin J2 is a member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer). It has a role as a human metabolite. It is functionally related to a prostaglandin D2.

As 15-deoxy-Δ12,14-prostaglandin J 2 (15d-PGJ 2) displays anti-oxidative, -inflammatory, and -cancer properties, we investigated whether this cyclopentenone PG, a stable degradation end-product of cyclooxygenase-generated PGD 2, exerts beneficial effects in three LUADC cell lines (A549, H1299, H23).

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC 50 of 7 μM [1] [2].

Sep 1, 1992 · Recently discovered properties of PGJ2 and related compounds include a stimulatory effect on osteogenesis and cellular responses that strikingly resemble that induced by heat shock. These PGs have also been found to induce y-glutamyl cysteine synthetase and elevate intracellular glutathione levels.

We focus on prostaglandin J2 (PGJ2) because it is highly neurotoxic compared to PGA1, D2, and E2. Unlike other PGs, PGJ2 and its metabolites have a cyclopentenone ring with reactive α,β-unsaturated carbonyl groups that form covalent Michael adducts with key cysteines in …

Delta-12-Prostaglandin J2 (Δ12-PGJ2) 是一种环戊烯酮前列腺素 (PG)，对多种肿瘤细胞的生长具有抗增殖作用。 Delta-12-Prostaglandin J2 是前列腺素 D2 的天然脱水产物，能够通过 caspase 激活诱导 HeLa 细胞的凋亡 (apoptosis)。

已有研究表明H-RAS可以被外源性15d-PGJ2激活，作者假设RAS的组成性激活可能驱动衰老，从而对dihomo-15d-PGJ2的升高作出反应。