2014年3月1日 · In the New York Heart Failure Registry, among 619 recently hospitalized patients with HFpEF, PH of moderate entity (average RV systolic pressure, 46 mm Hg) was detected in 44% of cases. 24 Data from Olmsted County database obtained by Doppler echocardiography show a PH rate that may be ≈80% when systemic hypertension is the main underlying ...

2022年5月30日 · 射血分数保留的心力衰竭 (HFpEF) 的 PH 与 1 型 PH (PAH) 具有相同的特征，但其血液动力学和病理生理学改变时什么呢？ 临床实践中最重要的 诊断 挑战之一是区分由原始肺动脉高压 (PAH) 引起的肺动脉高压 (PH) 和由左心疾病引起的 PH。 这两种情况具有一些共同的特征和病理生理途径，使得这两个过程在几个方面相似。 它们的诊断差异基于右心导管插入术、心脏结构改变和治疗反应的血流动力学数据。 更具体地说，继发于射血分数保留的心力衰竭 …

We highlight the underlying differences between PH-HFrEF and PH-HFpEF with the aim of guiding research efforts for novel therapies. Specifically, we focus on the characteristic derangements in left heart driving forces biological pathways, hemodynamics, and clinical phenotypes observed in the 2 HF conditions ( Central Illustration ).

2021年8月11日 · Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure and frequently is complicated by the development of pulmonary hypertension (PH). The prevalence of PH in HFpEF varies widely based on population, study design, the definition of PH, and diagnostic methods, with estimates ranging from 30% to 80%. 1 ...

Pulmonary hypertension (PH) is common in patients with heart failure with preserved ejection fraction (HFpEF). A chronic increase in mean left atrial pressure leads to passive remodeling in pulmonary veins and capillaries and modest PH (isolated postcapillary PH, Ipc-PH) and is not associated with significant right ventricular dysfunction.

2022年7月20日 · ph-hfpef的定义和流行率. 目前hfpef的定义在声明、指南和临床研究中差异很大，通常是基于超声心动图数据，而非肺动脉高压的“金标准”——右侧心导管检查(rhc)。目前对不同ph血流动力学的共识定义，以及临床试验和流行病学研究中使用的替代定义见表2。 表2

Heart failure with preserved ejection fraction (HFpEF) is defined as clinical features of heart failure, ideally with biomarker evidence such as elevated plasma natriuretic peptide levels, in the setting of an ejection fraction (EF) greater than 50% and imaging evidence of diastolic left ventricular dysfunction (1, 2).

2022年7月11日 · Heart failure (HF) with preserved ejection fraction (HFpEF) is one of the leading causes of pulmonary hypertension (PH) in the world. 1 The development of PH and particularly pulmonary vascular disease (which distinguishes functional pressure elevation from vascular dysfunction or remodeling) is among the strongest risk factors for adverse ...

Heart failure with preserved ejection fraction (HFpEF) and pulmonary arterial hypertension (PAH) are two emerging diseases focusing the attention of numerous researchers. In the last PAH guideline, there is a crossroad between the two diseases and pulmonary hypertension (PH) due to heart failure (HF) is categorized as subtype 2.

2020年9月1日 · Pulmonary hypertension (PH) associated with left heart disease, or Group 2 PH, includes heart failure, valvular heart diseases, and congenital heart diseases. Although it is axiomatic that in PH due to heart failure the increase in pulmonary pressure is directly related to an enhanced left atrial pr …