The PH domain of phosphoinositide-dependent kinase-1 exhibits …
2013年7月16日 · Phosphoinositide-dependent kinase-1 (PDK1) is an essential master kinase recruited to the plasma membrane by the binding of its C-terminal PH domain to the signaling …
Activation of the essential kinase PDK1 by phosphoinositide …
2022年4月6日 · We propose a model of lipid-dependent PDK1 activation in which PH domain-mediated autoinhibition is relieved by PIP 3 or PI (3,4)P 2 binding, leading to strongly …
The PH Domain of PDK1 Exhibits a Novel, Phospho-Regulated …
Phosphoinositide-Dependent Kinase-1 (PDK1) is an essential master kinase recruited to the plasma membrane by the binding of its C-terminal PH domain to the signaling lipid …
PI3K-AKT通路专题解析（下） - 知乎专栏
丝氨酸/苏氨酸激酶 AKT（又称作蛋白激酶 B 或Protein kinase B, PKB）作为一种原癌基因，已经成为医学界主要的关注热点，这是因为它在调控各种不同细胞功能（包括代谢、生长、增殖、 …
PDK1 controls upstream PI3K expression and PIP 3 generation
2013年7月29日 · Genetic deletion of 3-phosphoinositide-dependent protein kinase 1 (PDK1) or the pharmacological inhibition of its downstream effectors, that is, Akt and mammalian target …
3-Phosphoinositide-dependent protein kinase-1 (PDK1): …
1997年10月1日 · We recently identified a protein kinase, termed PDK1, that phosphorylates PKB at Thr308 only in the presence of lipid vesicles containing phosphatidylinositol 3,4,5 …
Activation of the essential kinase PDK1 by phosphoinositide …
2022年4月6日 · In this study, we have elucidated the mechanism of phosphoinositide-driven PDK1 auto-activation. We show that PDK1 trans-autophosphorylation is mediated by a PIP 3 …
High resolution crystal structure of the human PDK1 catalytic …
2002年8月8日 · 3-phosphoinositide dependent protein kinase-1 (PDK1) plays a key role in regulating signalling pathways by activating AGC kinases such as PKB/Akt and S6K. Here we …
CDD Conserved Protein Domain Family: PH_PDK1 - National …
2020年10月2日 · PDK1 contains an N-terminal serine/threonine kinase domain followed by a PH domain. Following binding of the PH domain to PtdIns(3,4,5)P3 and PtdIns(3,4)P2, PDK1 …
Modulation of the substrate specificity of the kinase PDK1 by …
2023年6月13日 · Our study reveals dynamic conformations of full-length PDK1 in which the location of the linker and the PH domain relative to the catalytic domain determines the …