2023年3月6日 · PHF2, a H3K9me2 demethylase, was identified to interact with AMPKα2. Genetic deletion of PHF2 aggravates lung cancer metastasis and abolishes the H3K9me2 downregulation and anti-metastasis...

2023年10月12日 · Plant homeodomain finger protein 2 (PHF2) demethylates lysine 9 in histone 3 (H3K9) and relieves gene silencing as an epigenetic regulator via its Jumonji C domain-dependent demethylase...

The N-terminal segment of PHF2 harboring both domain binds to H3K4me3 peptide with a K D of 160 nM, an affinity 4-fold higher than that of the isolated PHD domain of this enzyme. This finding demonstrates that additional domains of chromatin modifying enzyme may be necessary for optimal engagement of histone tail ligands by the PHD reader domains.

2024年6月18日 · The H3K9me2 demethylase PHF2 is essential for preserving heterochromatin stability and genome integrity in neural stem cells. PHF2 interacts with heterochromatin components at pericentromeric bound...

2019年7月30日 · Here, we demonstrate that the plant homeodomain finger protein 2 (PHF 2) histone demethylase is upregulated in the mouse hippocampus during the experience phase and plays an essential role in memory formation. PHF 2 promotes the expression of memory‐related genes by epigenetically reinforcing the TrkB– CREB signaling pathway.

2011年2月11日 · PHF2 belongs to a class of α-ketoglutarate-Fe 2 +-dependent dioxygenases. PHF2 harbors a plant homeodomain (PHD) and a Jumonji domain. PHF2, via its PHD, binds Lys4-trimethylated histone 3 in submicromolar affinity and has been reported to have the demethylase activity of monomethylated lysine 9 of histone 3 in vivo .

2023年4月14日 · In this review, we highlight the molecular mechanisms by which PHD fingers interact with ligands other than the amino terminus of H3 and discuss similarities and differences in engagement with histone and non-histone binding partners.

2024年12月25日 · PHF2 (PHD Finger Protein 2) is a Protein Coding gene. Diseases associated with PHF2 include Prostate Cancer and Autism Spectrum Disorder. Among its related pathways are Chromatin organization and RNA Polymerase I Promoter Opening.

该基因编码的蛋白质包含锌指样 PHD (植物同源结构域) 指，不同于其他类别的锌指基序，以及疏水且高度保守的结构域。 PHD 手指显示典型的 Cys4-His-Cys3 排列。 PHD 手指基因被认为属于一组不同的转录调节因子，可能通过影响染色质结构来影响真核基因表达。 [RefSeq 提供，2008 年 7 月] This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from Other classes of zinc finger motifs, and a hydrophobic and highly …

2014年7月21日 · As p53 is a critical tumor suppressor in colon cancer, we tested the possibility that PHF2 is an epigenetic regulator of p53. PHF2 was associated with p53, and thereby, promoted p53-driven gene...