2017年10月1日 · PhKv is a peptide isolated from the venom of the armed spider Phoneutria nigriventer. It has an antiarrythmogenic activity that involves the enhanced release of acetylcholine. The aim of this study was to investigate whether PhKv had an antinociceptive action in mice. Male albino Swiss mice (25–35 g) were used in this study.

PhKv-treated mice exhibited memory improvements comparable to galantamine- or vehicle-treated mice, indicating potential memory enhancement. Further analysis revealed memory improvement in both vehicle-treated and naive mutant mice. Conclusion: PhKv shows promise in memory improvement, warranting in-depth investigations into its mechanisms ...

The Phoneutria nigriventer peptide PhKv has shown a remarkable ability to rescue long-term memory in a mouse model of Alzheimer’s disease, due to its selective modulation of A-type transient outward K+ currents .

在神经性疼痛 (CCI) 和外周辣椒素试验中研究了 PhKv 的镇痛作用。 为了测试PhKv是否干扰胆碱能系统，用阿托品（5mg/kg，腹腔注射）或美加明（0.001mg/kg，腹腔注射）和PhKv毒素（30pmol/位点）或新斯的明预处理小鼠(100 pmol/位点)在足底内施用辣椒素(1 nmol/爪)之前15分 …

PhKv is a peptide isolated from the venom of the armed spider Phoneutria nigriventer. It has an antiarrythmogenic activity that involves the enhanced release of acetylcholine. The aim of this study was to investigate whether PhKv had an antinociceptive action in mice. Methods: Male albino Swiss mice (25-35g) were used in this study. The PhKv ...

In this study, we evaluated the effects of PhKv, a 4584 Da peptide isolated from the spider Phoneutria nigriventer venom, in the isolated rat heart and in isolated ventricular myocytes. Ventricular arrhythmias were induced by occlusion of the left anterior descending coronary artery for 15 min follo …

2025年1月9日 · This study explores the therapeutic potential of PhKv toxin, derived from the Brazilian wandering spider Phoneutria nigriventer, as an acetylcholinesterase inhibitor, aiming to prolong acetylcholine presence in the synaptic cleft of murine subjects.

Spider venom is a rich cocktail of neuroactive compounds designed to prey capture and defense against predators that act on neuronal membrane proteins, in particular, acetylcholinesterases (AChE) that regulate synaptic transmission through acetylcholine (ACh) hydrolysis - an excitatory neurotransmitter - and beta-secretases (BACE) that primarily...

2009年11月3日 · We investigated the effects of the native and recombinant PhKv spider toxin on cardiac arrhythmias during ischemia/reperfusion injury in isolated hearts and right atria. Purified PhKv contains 40 amino acids and a molecular weight of 4584 Daltons.

Conclusion: PhKv shows promise in memory improvement, warranting in-depth investigations into its mechanisms. Ongoing research explores the molecular aspects of PhKv’s action on acetylcholinesterase. Our study suggests PhKv’s therapeutic relevance in addressing cognitive deficits associated with acetylcholine dysregulation.