2013年12月1日 · This paper presents a rapid, simple and stability-indicating method based on HPLC–DAD that was developed for the separation and quantification of PHMB in liquid and gel-like pharmaceutical dosage forms without tedious sample preparation for the first time.

Using SIELC’s newly introduced BIST™ method, Polyhexanide (polyhexamethylene biguanide, PHMB) can be retained on a positively-charged anion-exchange BIST™ B+ column.

2019年12月1日 · In this work an efficient, sensitive, and high-resolution separation protocol was developed to perform quantitative measurements (sub-mg L−1) of alexidine dihydrochloride (ADH) and polyhexamethylene biguanide (PHMB) in commercial multipurpose contact lens solutions (MPS).

2013年12月1日 · A rapid and simple method for the determination of polyhexamethylene biguanide (polyhexanide, PHMB) in liquid and gel-like pharmaceutical formulations by means of high performance liquid...

2009年12月15日 · The objective of this study was to establish a reasonably simple and reliable method to measure very low concentrations of polyhexamethylene biguanide (PHMB) in multipurpose contact lens solutions (MPSs). By using a weak cation exchange solid phase extraction cartridge to extract the PHMB from MPS, …

A rapid and simple method for the determination of polyhexamethylene biguanide (polyhexanide, PHMB) in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection (HPLC-DAD) was developed. Best separation was achieved using a cy …

Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. We estimated that limit of detection is about 2 ppm for this compounds with this method. The peak of polyhexanide fractionated on several peaks due to difference in length of the polymer components.

Polyhexamethylene biguanide hydrochloride (PHMB-HCl, Fig. 1) is a cationic polyelectrolyte, and exhibits good bactericidal properties and low toxicity. PHMB is widely used for a disinfectant in personal-care products and for sanitizers in swimming pools.

In this brief brochure, SIELC now offers three different methods for PHMB analysis, each with its own unique benefits that can be used according to the specific analysis requirements your lab needs. The first method offered is quite useful when a group analysis of the entire range of molecular weights (MWs) of a sample of PHMB is required.

2009年8月31日 · In this article, the authors provides a thorough description of high-performance liquid chromatography (HPLC) for the determination of PHMB.HCL in the multipurpose solution. PHMB.HCL is an antiseptic belong to the biguanide group, which are cationic substances well known for their effective action against microbial infection.