Enhance your NF-κB research with the Phospho-NF-κB p65 (Ser536) Rabbit mAb, ideal for multiple applications including Western blot and flow cytometry

Polyclonal Antibody for studying NFkB-p65 (Ser536) phosphate. Validated for WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-NF-κB p65 (Ser536) Antibody (CST #3031) is ready to ship.

2024年12月25日 · p65磷酸化位点对PKC介导的信号转导通路具有重要的调控作用，磷酸化后的p65蛋白在核转运、DNA结合和转录活性等方面发生显著变化，进而影响下游基因的表达。

P65-pho is an antibody that detects phosphorylated NF-κB p65 subunit. It can be used in various applications to study the activation of the NF-κB signaling pathway. Automatically generated - may contain errors

Activation of the NF-κB signaling pathway by lipopolysaccharide (LPS) promotes inhibitor of NF-κBα (IκBα) degradation to allow nuclear translocation of the phosphorylated NF-κB p65 (pho-p65), resulting in up-regulation of the CCL-22 and PD-L1 genes in the B16F10 cells, as well as the CCL-22, PD-L1, TGF-β, and IL-10 genes in the RAW264.7 ...

The expression of p65, phosphorylated p65 (Pho-p65), and A20 (a negative regulator of NF-κB) was analyzed with senescent (S) and non-senescent (NS) human umbilical vein endothelial cells (HUVECs) by Western blotting.

2024年11月14日 · In addition to this, taraxerone inhibits the NF-κB pathway, a classical inflammation pathway, by the up-regulation of IκB and down-regulation of Pho-IκB and Pho-P65 (Fig. 1H). Since macrophage polarization is an essential part of the progression of ALI and M1 macrophages are the major effector cells of the inflammation, we examined the ratio ...

2024年11月14日 · This activation inhibited the NF-κB signaling pathway primarily through the dephosphorylation and deacetylation of p65. Simultaneously, taraxerone disrupted the NLRP3 inflammasome signaling pathway, thereby alleviating M1 polarization of macrophages and mitigating sepsis-induced pulmonary inflammation and oxidative stress.

2022年11月1日 · In stimulated cells, the activated the NF-κB pathway induced nuclear ectopic of the Pho-p65, leading to elevation of the B-cell lymphoma-2 (Bcl-2) expression levels and down-regulation of the Cleaved caspase 3 genes in both tumor cells, as well as up-regulation of the programmed cell death 1 ligand 1 (PD-L1) and nuclear factor of activated T ...

2014年10月26日 · Thymoquinone pretreatment significantly suppressed the phosphorylation and nuclear translocation of p65 induced by TNF-α (Fig. 5b–d). Immunofluorescence analysis also confirmed that thymoquinone pretreatment markedly restrained p65 from translocating to nucleus and phosphorylation induced by TNF-α (Fig. 5e).