Phosphoinositide-specific phospholipase C (PLC) is a key player in cell signaling processes. When cells encounter signals like hormones or growth factors, PLC breaks down a molecule …

Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors, and …

Three major pathways for activating phospholipase C (PLC). Open in a new tab PLC can be activated by either tyrosine kinase receptors, T-cell receptors, B-cell receptors, Fc receptors, …

Phospholipase C is a truly remarkable signalling moiety. We know of no other single enzyme that can produce (or modulate), directly, three distinct signals: inositol 1,4,5-trisphosphate (IP 3), …

Phospholipase C (PLC) plays pivotal roles in regulating various cellular functions by metabolizing phosphatidylinositol 4,5-bisphosphate in the plasma membrane. This process generates two …

Phospholipase C-protein kinase C signaling. Activation of GPCRs coupled to Gαq can recruit PLCβ to the membrane and activate its phospholipase activity via interactions with the GTP …

Are you researching molecular biology of Phospholipase C Signaling? Check out the QIAGEN pathway database for relevant molecules interactions. 🦠 Design custom dPCR assays and NGS …

2023年1月1日 · Phospholipase C (PLC) isoforms are involved in tissue-specific signaling and are triggered by a variety of signaling receptors, including G-protein coupled receptors and …

Recent studies reveal that, in addition to its enzymatic activity, PLC-γ regulates Ca 2+ entry via the formation of an intermolecular lipid-binding domain with canonical transient receptor …

2019年5月31日 · Phospholipase C pathways is one of the major intracellular signalling pathways regulating hormones. It functions to activate inositol lipid signalling pathways causing the …

Phospholipase C (PLC) is an essential mediator of cellular signaling. PLC regulates multiple cellular processes by generating bioactive molecules such as inositol-1,4,5-triphosphate (IP 3 ) …

Stimulation of phosphoinositide-hydrolysing phospholipase C (PLC) generating inositol-1,4,5-trisphosphate is a major calcium signalling pathway used by a wide variety of membrane …

Phospholipase C-epsilon (PLCε) integrates signaling from G-protein coupled receptors (GPCRs) to downstream kinases to regulate a broad range of biological and pathophysiological responses.

Phosphoinositide-specific phospholipases C (PI-PLCs) are a class of enzymes involved in the phosphatidylinositol metabolism, which is implicated in the activation of several signaling …

2017年1月27日 · Phospholipase C (PLC) is a key enzyme in phosphoinositide metabolism; in response to various stimuli, PLC hydrolyses phosphatidylinositol 4,5-bis-phosphate [PI(4,5)P …

2012年1月1日 · The physiological effects of many extracellular neurotransmitters, hormones, growth factors, and other stimuli are mediated by receptor-promoted activation of …

Equipped with a broad range of receptors, such as Toll-like receptor 4 (TLR4), CD14, and Fc gamma receptors (FcγRs), macrophages can efficiently recognize and phagocytize invading …

Our work identifies a conversion pathway and physiological function for PtdIns4P pools in rice and reveals the connection between phosphoinositides and Ca 2+ signals mediated by PLC during …

2 天之前 · Thouverey, C. & Caverzasio, J. Focus on the p38 MAPK signaling pathway in bone development and maintenance. Bonekey Rep. 4 , 711 (2015). Article CAS PubMed PubMed …

2025年1月27日 · Purpose Glucose starvation induces the accumulation of disulfides and F-actin collapse in cells with high expression of SLC7A11, a phenomenon termed disulfidptosis. This …