Pipeline for the identification of giant virus genomes from metagenomic datasets. GO check out BEREN. It has PIGv integrated inside of it and is much easier to install and run. It also has more functionality An easy to install and use pipeline to bin, clean, annotate, classify, and quantify genomes of giant viruses from metagenomic datasets.

2024年12月25日 · PIGV (Phosphatidylinositol Glycan Anchor Biosynthesis Class V) is a Protein Coding gene. Diseases associated with PIGV include Hyperphosphatasia With Impaired Intellectual Development Syndrome 1 and Neurodegeneration With Brain Iron Accumulation 2A.

The PIGV gene provides instructions for making an enzyme called GPI mannosyltransferase 2. This enzyme takes part in a series of steps that produce a molecule called a glycosylphosphosphatidylinositol (GPI) anchor.

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene. [5] [6]

Mutations in the PIGV, PIGO, or PGAP2 gene cause Mabry syndrome. These genes are all involved in the production (synthesis) of a molecule called a glycosylphosphosphatidylinositol (GPI) anchor. This molecule is synthesized in a series of steps.

2018年1月10日 · HGNC Approved Gene Symbol: PIGV. Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. The biosynthetic pathway of GPI is mediated by sequential addition of sugars and other components to phosphatidylinositol. PIGV adds the second mannose to the GPI core (Kang et al., 2005).

2024年3月5日 · Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome.

2013年10月16日 · Three different genes of the glycosylphosphatidylinositol anchor synthesis pathway, PIGV, PIGO, and PGAP2, have recently been implicated in hyperphosphatasia-mental retardation syndrome (HPMRS),...

At least 14 mutations in the PIGV gene have been found to cause Mabry syndrome, a condition characterized by intellectual disability, distinctive facial features, increased levels of an enzyme called alkaline phosphatase in the blood (hyperphosphatasia), and other signs and symptoms.

GPI-GnT enzyme adds glucosamine to the phosphatidylinositol; PIGM that encodes GPI-MT-I and the regulatory subunit PIGX transfer the first mannose to glucosamine. The GPI-MT-II encoded by PIGV transfers the second mannose, while GPI-MT-III encoded by PIGB binds the third mannose.