The PIN-4 antibody cocktail of P504S + p63 + High Molecular Weight Cytokeratin permits the simultaneous evaluation of prostate glands and the identification of cancerous foci on a single tissue section, using a two-color staining protocol. The PIN-4 cocktail has become the standard of care for the evaluation of prostate biopsies.

Get started here! Discover recipes, home ideas, style inspiration and other ideas to try.

It is a triple stain that is useful in distinguishing prostatic adenocarcinoma (variable AMACR/P504S red cytoplasmic staining with a lack of basal cell p63+HMWK brown staining) from the benign mimickers (with preserved basal cell brown staining of p63+HMWK and generally lack of red cytoplasmic staining of AMACR/P504S).

The combination of P504S + HMW CKs + p63 (PIN-4™ Cocktail) may be extremely useful for diagnosing prostatic intraepithelial neoplasia, especially in difficult cases, and in cases with limited tissues.

PIN4 or PIN-4 may refer to: PIN4, the gene encoding the protein Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4) PIN-4, a cocktail for immunohistochemistry, targeting TP63, CK-5, CK-14 and P504S

PIN is often described as either: Low-grade PIN if the patterns of prostate cells appear almost normal, or; High-grade PIN if the patterns of cells look more abnormal; Low-grade PIN. Many men begin to develop low-grade PIN at an early age, but low-grade PIN is not thought to be related to prostate cancer risk.

2024年12月25日 · PIN4 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4) is a Protein Coding gene. Diseases associated with PIN4 include Prostatic Acinar Adenocarcinoma and Non-Syndromic X-Linked Intellectual Disability .

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Protect paraffin block and/or slides from excessive heat.

2025年1月22日 · The combination of p63 + CK HMW + P504S (PIN-4 cocktail) can be extremely useful for diagnosing prostatic intraepithelial neoplasia (PIN) and/or prostate carcinoma, especially in difficult cases with limited tissue.

Virginia Urology, Richmond, VA, USA. Antibody cocktails combining basal cell markers (HMWCK, p63) with AMACR are useful in the evaluation of difficult prostate biopsies with limited tissue. Often the focus of concern consists of no more than a …