2012年9月27日 · TP53 encodes the multi-functional tumor suppressor transcription factor p53 which has a crucial role in maintaining genomic stability in somatic cells exposed to oncogenic or genotoxic stress, thus preventing tumor formation. 1 In response to a wide range of stress signals, p53 accumulates in the nucleus and regulates the expression of a large ...

2012年9月27日 · TP53 encodes the multi-functional tumor suppressor transcription factor p53 which has a crucial role in maintaining genomic stability in somatic cells exposed to oncogenic or genotoxic...

2019年3月11日 · PIN3 polymorphism is 16 base pairs duplication in intron 3 (PIN3), which reported that a significant functional effect on the mRNA splicing [14]. Several investigations have demonstrated the association between rs17878362 and rs1042522 polymorphisms with the increased risk of cancers such as ovarian, lung, colon, breast, esophageal, and gastric ...

2014年9月15日 · A single mutation of the allele with PIN3 duplication in PIN3 heterozygotes (A1/A2) might be partially responsible for TP53 haploinsufficiency. These findings may provide a new insight into the search for the unknown haploinsufficiency mechanism and …

Our results indicate that the TP53 PIN3 polymorphism has a sex-specific effect on the risk of cancer in TP53 mutation carriers, conferring cancer risk in men ( P = 0.0041) but not women with DI or II genotypes.

Our results indicate that the TP53 PIN3 polymorphism has a sex-specific effect on the risk of cancer in TP53 mutation carriers, conferring cancer risk in men (P = 0.0041) but not women with DI or II genotypes.

2012年9月27日 · p53 has a crucial role in human fertility by regulating the expression of leukemia inhibitory factor (LIF), a secreted cytokine critical for blastocyst implantation. To examine whether TP53 polymorphisms may be involved with in vitro fertilization (IVF) failure and endometriosis (END), we have asses …

The present study aimed to assess the association of PIN3 Ins16bp polymorphism of p53 with breast cancer risk in Moroccan population. This case-control study was performed on 105 female patients with confirmed breast cancer and 114 healthy controls.

2012年9月1日 · TP53 polymorphisms and haplotypes were identified by amplification refractory mutation system polymerase chain reaction. TP53 PIN3 and PEX4 were associated with both END (P=0.042 and P=0.007,...

TP53 encodes the multi-functional tumor suppressor tran-scription factor p53 which has a crucial role in maintaining genomic stability in somatic cells exposed to oncogenic or genotoxic stress ...