2010年10月17日 · Here we uncover an unexpected function of the piRNA pathway in the decay of maternal messenger RNAs and in translational repression in the early embryo. A subset of maternal mRNAs is degraded...

2010年10月28日 · Here we uncover an unexpected function of the piRNA pathway in the decay of maternal messenger RNAs and in translational repression in the early embryo. A subset of maternal mRNAs is degraded in the embryo at the maternal-to-zygotic transition.

2014年5月2日 · We demonstrate that a piRNA-induced silencing complex (pi-RISC) containing murine PIWI (MIWI) and deadenylase CAF1 is selectively assembled in ES, which is responsible for inducing mRNA...

2021年1月8日 · In early Drosophila embryos, the key piRNA pathway components Piwi, Aub, Ago3, Armitage (Armi), Spindle-E (Spn-E), and Squash (Squ) are all involved in the deadenylation and decay of maternal Nanos (Nos) mRNA through a piRNA targeting region in the nos 3′ UTR .

2021年10月13日 · Taken together, ribosomes binding to the piRNA precursor uppl mRNAs temporally stagger with other translation-dependent mRNA decay pathways, allowing massive piRNA production from mRNAs and...

2015年8月18日 · Base pairing between piRNAs and mRNAs can induce mRNA cleavage and decay that are essential for embryonic development. These results suggest general regulation of maternal mRNAs by Aub and piRNAs, which plays a key developmental role in the embryo through decay and localization of mRNAs encoding germ cell determinants.

2016年12月1日 · mRNA decay can be triggered by deadenylation or 3′-end modifications, like uridylation. Various dedicated decay pathways of non-protein coding RNAs exist in the cytoplasm. RNA decay plays a crucial role in post-transcriptional regulation of gene expression.

2015年8月18日 · Base pairing between piRNAs and mRNAs can induce mRNA cleavage and decay that are essential for embryonic development. These results suggest general regulation of maternal mRNAs by Aub and piRNAs, which plays a key developmental role in the embryo through decay and localization of mRNAs encoding germ cell determinants.

2015年8月18日 · Base pairing between piRNAs and mRNAs can induce mRNA cleavage and decay that are essential for embryonic development. These results suggest general regulation of maternal mRNAs by Aub and piRNAs, which plays a key developmental role in the embryo through decay and localization of mRNAs encoding germ cell determinants.

2020年11月30日 · Studies based on model organisms have shown that defects in the piRNA pathway exhibit impaired gametogenesis and loss of fertility. piRNA biogenesis is marked by transcription of precursor molecules and their subsequent processing in the …