2024年12月25日 · PITX1 (Paired Like Homeodomain 1) is a Protein Coding gene. Diseases associated with PITX1 include Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/Or Mirror-Image Polydactyly and Clubfoot. Among its related pathways is Beta-2 adrenergic-dependent CFTR expression.

Paired-like homeodomain 1 is a protein that in humans is encoded by the PITX1 gene. [5][6][7] This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in …

The PITX1 gene provides instructions for making a protein that plays a critical role in development of the lower limbs. The PITX1 protein is found primarily in the developing legs and feet. The protein acts as a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular ...

2021年12月13日 · We find that the over-representation of Pitx1 non/low-expressing cells originates from a failure of the Pitx1 locus to coordinate enhancer activities and 3D chromatin changes. This locus mis...

In mouse, Pitx1 regulates hindlimb tissue patterning and pituitary development. Pitx2 is essential for the development of the oral cavity and abdominal wall while regulates the formation and symmetry of other organs including pituitary, heart, gut, lung among others by controlling growth control genes upon activation of the Wnt/ß-catenin ...

2021年9月15日 · Here we show that paired-like homeodomain transcription factor 1 (PITX1) plays a crucial role in the inhibition of melanoma progression through regulation of SRY-box transcription...

2021年4月12日 · In mouse, Pitx1 regulates hindlimb tissue patterning and pituitary development. Pitx2 is essential for the development of the oral cavity and abdominal wall while regulates the formation and symmetry of other organs including pituitary, heart, gut, lung among others by controlling growth control genes upon activation of the Wnt/ß-catenin ...

该基因编码 RIEG/PITX 同源盒家族的一个成员，该家族属于同源域蛋白的二元类。 这个家族的成员参与器官发育和左右不对称。 这种蛋白质作为参与催乳素基础和激素调节活性的转录调节剂。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry.

Expression of Pitx1 in the adult pituitary is primarily in the corticotrophs, regulating POMC expression synergistically with Tpit. Pitx1 also appears to modulate Sf1 activity in gonadotrophs, activates the GH promoter, and synergistically activates the prolactin promoter with Pit1.

Combining gene targeting with chromatin immunoprecipitation sequencing (ChIP-seq) and transcriptomic analyses reveals that PITX1 cooperates with SOX2 and TRP63 to sustain an SCC-specific transcriptional feed-forward circuit that maintains TPC-renewal, while inhibiting KLF4 expression and preventing KLF4-dependent differentiation.