PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …

PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements …

PIWI-interacting RNAs (piRNA) suppress selfish genetic elements and are essential for germ cell biology in animals. They also play critical roles in regeneration in planaria, regulate gene …

PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a small RNA-based adaptive immune system that restricts the deleterious activity of mobile genetic elements to …

Recent studies indicate that the Piwi-piRNA pathway mediates epigenetic programming and posttranscriptional regulation, which may be responsible for its function in germline …

2014年1月15日 · This paper shows the direct interaction between Piwi and HP1a, the binding of Piwi to chromosomes in Drosophila somatic cells and the epigenetic effect of such interaction …

Modulation of chromatin is a key factor in most DNA repair pathways (Cann and Dellaire, 2011), and PIWI’s involvement in this facet of genome stability is intriguing especially given its role as …

2017年12月1日 · Molecular findings reveal that PIWI2 acts as a guard against DNA damage by maintaining the open state of chromatin via histone modification and thereby it supports DNA …

In this review, we discuss the biological functions of Piwi proteins in animal germ cells and stem cells. Piwi proteins are required to maintain fertility and repress transposons in the germline …

2011年3月23日 · PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the piRNA-induced silencing complex (piRISC) in the germ line of many animal …