PIWI-interacting RNAs: small RNAs with big functions
2018年11月16日 · PIWI-interacting RNAs (piRNAs) are an animal-specific class of small silencing RNAs, distinct from microRNAs (miRNAs) and small interfering RNAs (siRNAs). piRNAs bear 2ʹ- O -methyl-modified 3ʹ...
Mammalian PIWI–piRNA–target complexes reveal features for …
2024年4月24日 · Here, we show that mouse MILI and human HILI piRNA-induced silencing complexes (piRISCs) bind and cleave targets more efficiently than their invertebrate counterparts from the sponge Ephydatia...
Nature报道丨西湖大学科研团队首次揭示“RNA剪刀”切割全过程
北京时间2025年1月15日24时，西湖大学生命科学学院、西湖实验室申恩志团队联合吴建平团队在Nature杂志上在线发表了题为“Structural insights into RNA cleavage by PIWI Argonaute”的研究成果。
piRNA：一类可能会火起来的非编码RNA - 知乎 - 知乎专栏
piRNA（PIWI-interacting RNA），是一种长25～33nt的非编码RNA，通过与PIWI蛋白相互作用而发挥作用，虽然同为非编码RNA，piRNA却远没有miRNA、LncRNA、circRNA知名度高，主要是因为piRNA主要在生殖系统中表达，相…
Piwi - Wikipedia
Piwi is an abbreviation of P-element Induced WImpy testis [a] in Drosophila. [6] Piwi proteins are highly conserved RNA-binding proteins and are present in both plants and animals. [7] Piwi proteins belong to the Argonaute/Piwi family and have been classified as nuclear proteins.
Novel roles of PIWI proteins and PIWI-interacting RNAs in human …
2023年11月29日 · Non-coding RNA has aroused great research interest recently, they play a wide range of biological functions, such as regulating cell cycle, cell proliferation, and intracellular substance metabolism. Piwi-interacting RNAs (piRNAs) are emerging small non-coding RNAs that are 24–31 nucleotides in length.
PIWI‐interacting RNA MIABEPIR regulates cerebral endothelial cell ...
2025年2月25日 · PIWI-interacting RNA MIABEPIR regulates cerebral endothelial cell function via DAPK2 pathway in offspring following maternal immune activation ... was thawed overnight at 4°C. Both 200 µL pipette tips and a 96-well plate were pre-cooled. A total of 70 µL of Matrigel was dispensed into each well of a pre-chilled plate and allowed to solidify ...
PIWI proteins and PIWI-interacting RNAs in the soma - Nature
2014年1月15日 · This paper shows the direct interaction between Piwi and HP1a, the binding of Piwi to chromosomes in Drosophila somatic cells and the epigenetic effect of such interaction and binding.
Nat Rev Mol Cell Bio（IF=114）| 发表piRNA的新兴作用和功能机 …
PIWI 相互作用的 RNA (piRNA) 是一类与 Argonaute 家族的 PIWI 进化枝的蛋白质相关的小型非编码 RNA。 首先在动物生殖系细胞中发现，piRNA 在生殖系发育中具有重要作用。
科学网—林海帆教授综述：PIWI蛋白和piRNA对基因表达的调控
2014年7月16日 · 小非编码RNA中，微RNAs (microRNAs, miRNAs)与小干扰RNA (small interfering RNAs,siRNAs)长约21个核苷酸，与ARGONAUTE (AGO)/PIWI蛋白家族中的AGO亚族结合。 另一类小非编码RNA称作piRNAs (PIWI-interacting RNAs)，长度为24–32个核苷酸，则是与AGO/PIWI蛋白质家族的PIWI亚族结合。 piRNA主要表达于生殖细胞中。 生殖细胞中存在了数以百万的piRNA序列，其数目远远超过其他非编码RNA总和。 更惊人的是，piRNA序列可对应到 …