2014年1月15日 · In this Review, we focus on the role of the PIWI–piRNA pathway in the soma of diverse organisms, from basal eukaryotes to humans.

We showed previously that Piwi, a key component of the piRNA pathway in Drosophila, is regulated in somatic cells by Yb, a novel protein containing an RNA helicase-like motif and a Tudor-like domain. Yb is specifically expressed in gonadal somatic cells and regulates piwi in somatic niche cells to control germ line and somatic stem cell self ...

2025年1月15日 · These findings explain the molecular mechanisms underlying PIWI–PIWI-interacting RNA complex function in target RNA cleavage, providing insights into how dynamic conformational changes from...

PIWI proteins play crucial roles during germline development and gametogenesis of many metazoan species, from germline determination and germline stem cell maintenance to meiosis, spermiogenesis, and transposon silencing.

2018年11月16日 · PIWI-interacting RNAs (piRNAs) are an animal-specific class of small silencing RNAs, distinct from microRNAs (miRNAs) and small interfering RNAs (siRNAs). piRNAs bear 2ʹ- O...

piRNA 是一类存在于动物生殖细胞中,长25~ 32 nt 的非编码小RNA ,能与PIWI家族蛋白结合形成piRNA 沉默复合物(piRNA-induced silencing complex, piRISC)来调控转座子和重复序列等基因组自私性遗传元件的活性,保证生殖系细胞基因组的稳定性和完整性[1]。 转座子是一类由基因组自身编码的可移动遗传因子,分为DNA 转座子和RNA介导的反转录转座子,可以通过移动或复制到新的位置影响基因组的信息和组织,导致基因组完整性的缺失[2], 熟的piRNA ,随后被加载到PIWI蛋白上 …

2024年3月21日 · 大量研究显示 PIWI/piRNA 通路与一些生精细胞特异性生殖颗粒偶联。特别是，位于线粒体簇间的 Intermitochondrial cement （ IMC ）和细胞核周的 Chromatoid body （ CB ）被分别认为是 piRNA 加工成熟和功能的场所，也是被研究得最清楚的两种生殖颗粒。

PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons.

2022年9月14日 · PIWI-interacting RNAs (piRNAs) are small non-coding RNAs with essential roles in germ line development through silencing of transposable elements and in regulation of protein-coding genes.

2024年9月26日 · PIWI-interacting RNAs (piRNA) suppress selfish genetic elements and are essential for germ cell biology in animals. They also play critical roles in regeneration in planaria, regulate gene expression in adult mammalian testes, …