Piwi-interacting RNA (piRNA) is the largest class of small non-coding RNA molecules expressed in animal cells. [1] [2] [3] piRNAs form RNA-protein complexes through interactions with piwi-subfamily Argonaute proteins.

2018年11月16日 · In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence transposable elements, regulate gene expression and fight viral infection. piRNAs guide PIWI proteins...

piRNA （PIWI-interacting RNA），是一种长25～33nt的非编码RNA，通过与 PIWI蛋白 相互作用而发挥作用，虽然同为非编码RNA，piRNA却远没有miRNA、LncRNA、 circRNA 知名度高，主要是因为piRNA主要在生殖系统中表达，相关研究也大多集中于此。

PIWI-interacting RNAs (piRNA) suppress selfish genetic elements and are essential for germ cell biology in animals. They also play critical roles in regeneration in planaria, regulate gene expression in adult mammalian testes, and participate in antiviral defense in mosquitoes.

PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24-31 nucleotides in length. They associate with PIWI proteins, which constitute a germline-specific subclade of the Argonaute family, to form effector complexes known as piRNA-induced silencing complexes, which repress transposons vi …

2022年9月14日 · PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells, piRNAs...

PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) constitute a small RNA-based adaptive immune system that restricts the deleterious activity of mobile genetic elements to protect genome integrity. Self/nonself discrimination is at the very core of successful defence and relies on complementary base-pairing in RNA-guided immunity.

PIWI-interacting RNA (piRNAs), once thought to be mainly functioning in germlines, are now known to play an essential role in somatic and cancerous tissues. Ping-pong cycle initiation and mitochondria-based phased production constitute the core of the piRNA biogenesis and these two processes are well conserved in mammals, including humans.

2011年3月23日 · PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that protect the integrity of the genome by silencing transposable elements in both germline and...

In animals, PIWI-interacting RNAs (piRNAs) of 21-35 nucleotides in length silence transposable elements, regulate gene expression and fight viral infection. piRNAs guide PIWI proteins to cleave target RNA, promote heterochromatin assembly and methylate DNA.