2024年12月25日 · PKDCC (Protein Kinase Domain Containing, Cytoplasmic) is a Protein Coding gene. Diseases associated with PKDCC include Rhizomelic Limb Shortening With Dysmorphic Features and Short Stature And Advanced Bone Age With Or Without Early-Onset Osteoarthritis And/Or Osteochondritis Dissecans.

2025年2月8日 · Enables non-membrane spanning protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation and skeletal system development. Located in extracellular region. [provided by Alliance of Genome Resources, Feb 2025]

2024年6月17日 · Enables non-membrane spanning protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation and skeletal system development. Located in extracellular …

Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. The RNA data was used to cluster genes according to their expression across cell lines.

Broad expression in ovary (RPKM 28.2), endometrium (RPKM 26.6) and 22 other tissues. 启用非跨膜蛋白酪氨酸激酶活性。 参与肽酰酪氨酸磷酸化和骨骼系统发育。 位于胞外区。 [由基因组资源联盟提供，2022 年 4 月] Enables non-membrane spanning protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation and skeletal system development.

2015年8月13日 · Protein Kinase Domain Containing, Cytoplasmic (PKDCC) is a protein kinase which has been implicated in longitudinal bone growth through regulation of chondrocytes formation. Nevertheless, the mechanism by which this occurs remains unknown. Here, we identified two new members of the PKDCC family, Pkdcc1 and Pkdcc2 from Xenopus laevis.

HGNC Approved Gene Symbol: PKDCC. Cytogenetic location: 2p21 Genomic coordinates (GRCh38) : 2:42,048,021-42,058,517 (from NCBI) PKDCC is a protein kinase that is initially expressed in E-cadherin (CDH1; 192090)-positive cells but is later confined in E-cadherin-negative cells (Kinoshita et al., 2009).

Homozygous null mutants die on postnatal day P0, apparently due to ineffective respiration. They exhibit shortening of all the long bones of the fore- and hindlimbs, cleft palate, sternal …

2023年11月23日 · Clinical resource with information about PKDCC, A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS)., Genome-wide association analyses identify variants in developmental genes associated with hypospadias., Genome-wide meta-analysis identifies 56 …

2010年2月7日 · Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405).