Placental growth factor (PlGF) is an increasingly important player in the clinical management of pre-eclampsia. This review outlines the role of PlGF in human physiology but focuses specifically on the current understanding of PlGF’s function in …

2021年4月12日 · PlGF status distinguished placental from fetal causes of stillbirth. Low PlGF levels in high-risk pregnant women are strongly associated with increased rates of imminent preterm birth, as well as related adverse outcomes, including early-onset preeclampsia and …

2022年7月27日 · Evidence-based recommendations on placental growth factor (PLGF)-based testing to help diagnose suspected preterm pre-eclampsia. The tests are: DELFIA Xpress PLGF 1 2 3, DELFIA Xpress sFlt 1/PLGF 1 2 3 ratio, Elecsys immunoassay sFlt …

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and is principally expressed in the placenta; it is associated with angiogenesis and plays a role in trophoblast growth and differentiation.

2017年8月24日 · Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the...

Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports trophoblast growth.

Placental growth factor (PlGF) is expressed in the placenta and is essential for placental angiogenesis and maintenance of the maternal endothelium.3,4 In a healthy pregnancy, PlGF concentration increases until about pregnancy week 30, reflecting placental angiogenesis and a healthy endothelium (see High PlGF bioavailability).5

Although first identified in placenta, the angiogenic factor known as placental growth factor (PlGF) can be widely expressed in ischemic or damaged tissues. Recent studies have indicated that PlGF is a relevant factor in the pathobiology of blood ...

2022年7月11日 · Maternal PlGF, sFlt-1 and sFlt-1/PlGF ratio show good performance for screening and diagnosing PE, for predicting development of PE in the short term, for monitoring established PE and for predicting other placenta-related disorders.

2019年5月4日 · Our stepped-wedge cluster-randomised controlled trial provides evidence of the clinical effects of PlGF-based testing on the time to diagnosis and maternal and perinatal outcomes in women with suspected pre-eclampsia.