2021年4月12日 · PlGF status distinguished placental from fetal causes of stillbirth. Low PlGF levels in high-risk pregnant women are strongly associated with increased rates of imminent preterm birth, as well as related adverse outcomes, including early-onset preeclampsia and …

In normal pregnancy, concentrations of PlGF are low in the first trimester and increase thereafter, with a peak around 30 weeks and subsequent decline. PlGF is found to be decreased in women prior to the onset as well as during the clinical phase of pre-eclampsia [4,5]. The serum marker has been targeted to aid in the diagnosis pre-eclampsia.

2022年7月27日 · Evidence-based recommendations on placental growth factor (PLGF)-based testing to help diagnose suspected preterm pre-eclampsia. The tests are: DELFIA Xpress PLGF 1 2 3, DELFIA Xpress sFlt 1/PLGF 1 2 3 ratio, Elecsys immunoassay sFlt …

Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of mid-pregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later life cardiovascular risk.

Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports trophoblast growth. Mechanisms by which PlGF expression is …

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor family and is impli-cated in angiogenesis and trophoblastic invasion of the maternal spiral arteries1–3.

2024年11月5日 · In pregnancy, PlGF stimulates neo-angiogenesis, contributing to the transformation of the uteroplacental vasculature into a low-resistance system. During a low-risk pregnancy, PlGF increases as the gestation advances, …

2022年7月11日 · In this Review, we summarize the existing knowledge, examining the performance of maternal PlGF, sFlt-1 and the sFlt-1/PlGF ratio for screening PE, predicting development of PE in the short term, diagnosing PE, monitoring established PE and predicting other placenta-related disorders in singleton pregnancy.

Placental growth factor (PlGF) is an increasingly important molecule in the prediction, diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental circulation and supports trophoblast growth.

Accurate diagnosis of preterm preeclampsia (PE) may improve the management of affected pregnancies. Previous studies have demonstrated that reduced levels of Placental growth factor (PlGF) levels (< 100 pg/mL) provide superior diagnostic performance to evaluate pregnant individuals with suspected hypertension.