2024年9月5日 · Plasma membrane transporter Progressive Ankylosis Protein Homolog (ANKH/Ankh) mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation and ageing

Our current data firmly link a specific membrane protein, ANKH, to extracellular citrate disposition in vivo and are in line with a GWAS study describing a correlation between plasma citrate levels and certain ANKH variants in humans .

The plasma membrane protein Ankylosis Homologue (ANKH, mouse ortholog: Ank) prevents pathological mineralization of joints by controlling extracellular levels of the mineralization inhibitor pyrophosphate (PPi). It was long thought that ANKH acts by transporting PPi into the joints.

2024年8月30日 · We show here that EC is mediated by a newly described plasma membrane citrate transporter ANKH/SLC62A1 (progressive human ankylosis -ANKH) in senescent fibroblasts. Analogous to interleukin 6 (IL-6), EC and/or ANKH are regulated by telomere dysfunction, the p38 mitogen-activated kinase axis and transforming growth factor beta, but not by ...

膜转运蛋白进行性强直蛋白同源物 （ANKH/Ank） 部分介导衰老衍生的细胞外柠檬酸盐，并受 DNA 损伤、炎症和衰老的调节。 bioRxiv - Cell Biology Pub Date : 2025-02-19, DOI: 10.1101/2024.08.30.609895

2022年2月11日 · 质膜蛋白强直同源物（ANKH，小鼠直系同源物：Ank）通过控制矿化抑制剂焦磷酸盐 (PPi) 的细胞外水平来防止关节的病理性矿化。 长期以来，人们一直认为 ANKH 通过将 PPi 输送到关节中发挥作用。

2022年2月11日 · The plasma membrane protein ankylosis homologue (ANKH, mouse ortholog: Ank) prevents pathological mineralization of joints by controlling extracellular levels of the mineralization inhibitor pyrophosphate (PPi).

2025年2月8日 · ANKH genetic polymorphisms in the area between SNP rs2291943 and rs2288474 are strongly associated with OPG plasma levels. Numerous ANKH gene mutations cause familial calcium pyrophosphate dihydrate deposition disease; they enhance ANKH protein activity, elevating extracellular pyrophosphate levels …

2011年1月1日 · PPi can be generated by metabolism of extracellular ATP by the phosphodiesterase ENPP1, also known as plasma cell membrane glycoprotein-1 (PC-1), and by the transport of intracellular PPi from cells by the transmembrane-spanning cell surface protein ANKH, the human homolog of the mouse progressive Ank.

ANKH (or the mouse ortholog Ank) encodes a novel 492-aa multipass transmembrane protein (ANKH/ANK) that is hypothesized to transport PPi ions across the plasma membrane to the extracellular environment. 3 The importance of Ank was first elucidated in mice when it was shown that a spontaneous mutation called “progressive ankylosis” (ank ...