The structure of plastin has been evolutionarily maintained within organisms who utilize this protein, which includes humans and lower eukaryotic organisms. Plastin structures are known …

Plastins are characterized by EF-hand Ca 2+ -binding domains and actin-binding domains and can cross-link actin filaments into higher-order assemblies like bundles. Three isoforms have …

Elevated PLS3 levels are considered a prognostic biomarker for cancer and refractory response to therapies. When it is knocked out or mutated in humans and mice, it causes osteoporosis …

2022年5月19日 · Plastins/fimbrins are conserved actin-bundling proteins contributing to motility, cytokinesis and other cellular processes by organizing strikingly different actin assemblies as …

plastin（也称为fimbrin）蛋白家族属于肌动蛋白捆绑蛋白，并且该蛋白家族在酵母，植物和动物细胞中具有进化保守性并在其中表达。 弹性蛋白的特征在于EF-手Ca 2+结合结构域和肌动蛋白 …

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin …

2020年11月22日 · L-Plastin （ LPL ）是肌动蛋白捆绑蛋白 Plastin 蛋白家族成员之一，其广泛表达于哺乳动物的髓系细胞中，如巨噬细胞，淋巴细胞，在细胞伪足形成，细胞迁移等过程中发挥 …

2020年9月23日 · We show that T-Plastin widens and lengthens protrusions and is specifically enriched in active protrusions where F-actin is devoid of non-muscle myosin II activity. …

2013年4月1日 · PLS3 is a novel marker for metastatic CRC cells, and it possesses significant prognostic value. ©2012 AACR. Circulating tumor cells (CTC) in blood have attracted attention …

The actin-bundling protein L-plastin (LPL) mediates the resorption activity of osteoclasts, but its therapeutic potential in pathological bone loss remains unexplored. Here, we report that LPL …