2024年12月25日 · PLD1 (Phospholipase D1) is a Protein Coding gene. Diseases associated with PLD1 include Cardiac Valvular Dysplasia 1 and Heart Disease. Among its related pathways are Glycerophospholipid biosynthesis and Signaling by Rho GTPases.

Phospholipase D1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, [5][6] though analogues are found in plants, fungi, prokaryotes, and even viruses. [7] The possibility of PLD1 was first mentioned in 1947 by authors Hanahan and Chaikoff at Berkeley when describing a carrot enzyme that could " [split] choline from phospholipids." [8]

2024年7月1日 · PLD1 inhibition specifically targets GSCs but not neuroprogenitor cells. PLD1 depletion sensitizes GSCs to the effect of TMZ on GSC‐derived intracranial tumors 17.

2019年10月18日 · 10 月 16 日， Cell research 在线发表了中国科学院分子植物科学卓越创新中心张鹏研究组题为 Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D 的研究论文。 该研究解析了植物磷脂酶 Dα1 及其与产物磷脂酸 (PA) 复合体的晶体结构，详细阐释了真核生物磷脂酶 D 催化磷脂产生磷脂酸及其活性调节的分子机制。 磷脂酶（Phospholipase, PL）催化细胞膜上磷脂的水解。 根据水解部分的不同，人们将磷脂 …

2017年2月17日 · The phospholipase D (PLD) isoenzymes PLD1 and PLD2 are one of the major sources of signal-activated phosphatidic acid (PtdOH) generation downstream of a variety of cell-surface...

2021年1月1日 · As a promising pharmaceutical target, the biochemical properties of PLD have been well characterized. This has led to the recent crystal structures of human PLD1 and PLD2, the development of PLD specific pharmacological inhibitors, and the identification of cellular regulators of PLD.

2020年3月16日 · The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease...

Phospholipase D1 (PLD1) is generally accepted as playing an important role in the regulation of multiple cell functions, such as cell growth, survival, differentiation, membrane trafficking, and cytoskeletal organization. Recent findings suggest that …

PLD1 and PLD2 are indispensable for M1 polarization and M2 polarization, respectively. Genetic and pharmacological targeting of PLD1 conferred protection against LPS-induced sepsis, cardiotoxin-induced muscle injury, and skin injury by promoting the shift toward M2; PLD2 ablation intensified disease severity by promoting the shift toward M1.

PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta and src dependent mechanism; PLD1 may play a crucial role in collagen type I production through mTOR signaling in human dermal fibroblast. phospholipase D suppresses protein phosphatase 2A and is involved in the mTOR survival pathway in the transformation of human cells