In general, CD8-positive lymphocytes dominated in cases of PLEVA, whereas CD4-positive lymphocytes were very conspicuous and composed the dominant intraepidermal populace only in those biopsies of progressive PL/PLC. Clonality was shown in 25 of 27 biopsies in which amplifiable DNA was obtained.

Pityriasis lichenoides comprises a clinicopathologic spectrum of cutaneous inflammatory disorders, with the 2 most common variants being pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica. The aim of the study was to describe 13 cases of a unique PLEVA variant …

Pityriasis lichenoides (PL), an uncommon dermatitis, previously included in the parapsoriasis group, may appear in two clinical forms: the acute variant also known as pityriasis lichenoides et varioliformis acuta (PLEVA); and the chronic variant or pityriasis lichenoides chronica (PLC) .

Histologically, both PLEVA and PLC are characterized by dense lymphocytic infiltrates in the dermis, with CD8 lymphocytes predominating in PLEVA and CD4 lymphocytes in PLC. PLEVA usually resolves in a few months, although it can persist.

2023年1月2日 · Pityriasis lichenoides et varioliformis acuta (PLEVA), also known as Mucha-Habermann disease, is an uncommon cutaneous inflammatory rash characterized by diffuse red-brown papules in various stages with a mica-like scale on more established lesions.

Results: The numbers of CD8 + T cells and T-cell intracellular antigen-1 (TIA-1) + cells were statistically significantly higher in PLEVA compared to the ID group. Immunohistochemistry for human HHV-1 and HHV-2, CMV and HHV-8, parvovirus B19, and in situ hybridization for EBV were all negative.

2024年7月7日 · Formalin-fixed, paraffin-embedded specimens of 20 patients with PLEVA and 9 patients with common inflammatory dermatoses (ID) were studied for immunophenotyping and for human herpesvirus (HHV) 1 and 2, cytomegalovirus (CMV), HHV-8, parvovirus B19, and Epstein–Barr virus (EBV) immunohistochemistry.

Tanto la pitiriasis liquenoide y varioliforme aguda (PLEVA) como la pitiriasis liquenoide crónica representan 2 extremos de un espectro de enfermedad en el que coexisten ambas entidades y formas intermedias 1.

PITYRIASIS lichenoides chronica (PLC) is a benign, acquired, idiopathic dermatosis characterized by recurrent crops of scaling papules, which may resolve spontaneously over weeks to months or follow a more indolent course. 1 Histologically, PLC exhibits a superficial perivascular lymphohistiocytic infiltrate, parakeratosis, vacuolization of ...

Therefore, we studied T-cell clonality in cutaneous lesions of 20 clinically and histologically typical cases of PLEVA from a university hospital using sensitive polymerase chain reaction (PCR) amplification followed by heteroduplex analysis of the TCRγ gene, a reliable and sensitive method to detect the presence of a dominant T-cell clone in ...