2024年12月25日 · PLXNA2 (Plexin A2) is a Protein Coding gene. Diseases associated with PLXNA2 include Gaba Aminotransferase Deficiency and Loeys-Dietz Syndrome 5. Among its related pathways are Semaphorin interactions and Nervous system development.

This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [6] In some studies, the PLXNA2 gene is associated with schizophrenia. [7] and anxiety. PLXNA2 is a candidate gene for intellectual disability and possibly …

Our study showed that PLXNA2 knockdown accelerated the recovery of motor function and cognitive ability after MCAO/R. In addition, PLXNA2 knockdown restrained proinflammatory cytokine release and promoted anti-inflammatory cytokine release, and the mammalian target of rapamycin (mTOR)/signal transducer and activator of transcription 3 (STAT3 ...

信号蛋白的一个子集被 plexin-A/neuropilin 跨膜受体复合物识别，触发导致轴突排斥的细胞信号转导级联。 该 plexin-A 家族成员被认为可转导信号素 3A 和 -3C 的信号。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the plexin-A family of semaphorin co-receptors.

2025年2月8日 · Data suggest that Fyn tyrosine kinase (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal transduction. Title: Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.

Plexin-A2 是一种 蛋白质，在人类中被 PLXNA2 基因 编码。 该基因编码了 plexin -apemaphorin 共受体 家族 的成员。 信号素是一个大型分泌或膜结合蛋白的家族，在神经系统发育过程中介导对 轴突探路的 排斥作用。

semaphorins是一大类可分泌或膜结合的蛋白质，在神经系统发育过程中对轴突路径的识别具有排斥作用。 一部分semaphorins被plexin-A/神经磷脂跨膜受体复合物识别，触发细胞信号转导级 …

与人PLXNA2（plexin A2）正同源。 [由基因组资源联盟，2022年4月提供] Lineage-specific biology revealed by a finished genome assembly of the mouse. 具有相同的蛋白质结合活性，并参与信号肽受体活性。 参与细胞迁移和信号肽-plakin信号通路调节。 在几个过程的上游或内部发挥作用，包括小脑颗粒细胞前体切线迁移；脊索动物胚胎发育；和肢芽形成。 是质膜的完整组件。 在几个结构中表达，包括生殖系统；心脏；肺；神经系统；和感觉器官。 与 …

Enables identical protein binding activity and semaphorin receptor activity. Involved in regulation of cell migration and semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including cerebellar granule cell precursor tangential migration; chordate embryonic development; and limb bud formation.

2024年3月5日 · Clinical resource with information about PLXNA2, Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.