2024年12月25日 · ZBTB16 (Zinc Finger And BTB Domain Containing 16) is a Protein Coding gene. Diseases associated with ZBTB16 include Skeletal Defects, Genital Hypoplasia, And Impaired Intellectual Development and Acute Promyelocytic Leukemia. Among its related pathways are Class I MHC mediated antigen processing and presentation and …

2015年7月16日 · In this study, we used sensitive genetic-based approaches to assess the induction of PLZF expression in non-innate T cells by T cell receptor (TCR)-mediated activation. Surprisingly, we found...

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene. This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus.

It is a transcriptional repressor involved in cell cycle control and has been implicated in limb development, differentiation of myeloid cells, and spermatogenesis. Little is known about the regulation of PLZF expression.

早幼粒细胞白血病锌指蛋白（promyelocytic leukemia zinc finger，PLZF），也被称为ZBTB16 (zinc finger and BTB domain containing 16，ZBTB16)或锌指蛋白145 (zinc finger protein...

Recent studies have identified two direct transcriptional targets of PLZF, REDD1 and smooth muscle α-actin. REDD1 is activated by PLZF. It mediates the PLZF-dependent downregulation of TORC1 and is responsible for the maintenance of pluripotency in cultures of spermatogonial progenitor cells. This activity may extend to other stem-like cell types.

In this study, we show that among CD56 bright intrahepatic NK (ihNK) cells, PLZF is highly associated with markers of liver residency. We report the existence of a small population of PLZF hi CD56 bright NK cells in peripheral blood, expressing the liver‐homing receptors CXCR6 and CD69 and sharing functional characteristics with lrNK cells.

2021年11月11日 · Here we show that PLZF/ZBTB16 and its fusion proteins are pomalidomide-dependent neosubstrates of CRL4 CRBN. PLZF joins to RARα or potentially other partner genes, and the translocation causes...

2004年5月23日 · Here we show that Zfp145, encoding the transcriptional repressor Plzf, has a crucial role in spermatogenesis. Zfp145 expression was restricted to gonocytes and undifferentiated spermatogonia and...

We report that PLZF (promyelocytic leukemia zinc finger; Zbtb16), a member of the BTB/POZ-ZF family of transcription factors which includes the CD4 lineage-specific c-Krox (Th-POK, Zbtb7b), is exquisitely specific to CD1d-restricted NKT cells and human MR1-specific MAIT cells.