2020年2月26日 · Pogo transposable element derived with ZNF domain (POGZ) has been identified as one of the most recurrently de novo mutated genes in patients with neurodevelopmental disorders (NDDs),...

We found that the loss of POGZ reduced neural stem cell proliferation in excitatory cortex-patterned neural rosettes, structures analogous to the cortical ventricular zone in human fetal brain. As a result, fewer intermediate progenitor cells and early born neurons were generated.

2010年6月20日 · We have identified a unique HP1α-binding protein, POGZ (pogo transposable element-derived protein with zinc finger domain), using an advanced proteomics approach. Proteins generally interact with...

2024年12月25日 · POGZ (Pogo Transposable Element Derived With ZNF Domain) is a Protein Coding gene. Diseases associated with POGZ include White-Sutton Syndrome and Nail Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD1.

2021年12月7日 · Here we reveal the genomic binding of POGZ in the developing forebrain at euchromatic loci and gene regulatory elements (REs). We profile chromatin accessibility and gene expression in Pogz−/− mice and show that POGZ promotes the active chromatin state and transcription of clustered synaptic genes.

Pogo transposable element with ZNF domain is a protein that in humans is encoded by the POGZ gene. [5] [6] The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system.

2021年11月10日 · Here, we show that the zinc finger protein POGZ promotes the presence of HP1 at DNA double‐strand breaks (DSBs) in human cells. POGZ depletion delays the resolution of DSBs and sensitizes cells to different DNA‐damaging agents, including cisplatin and …

2019年3月16日 · POGZ (pogo transposable element-derived protein with zinc finger domain) gene encodes a multi-domain protein that regulates chromatin remodeling, chromosome segregation, and mitotic progression. Pathogenic POGZ mutation makes the majority of cells to exit mitosis prematurely with the formation of polyploid cells, which subsequently causes cell ...

pogz是神经发育障碍和神经精神疾病患者中最经常发生突变的基因之一，包括引发精神分裂症、神经外胚层衍生的智力障碍和自闭症谱系障碍等疾病。然而，由pogz突变引起的神经发育紊乱的潜在病因仍然难以确定。人们对其…

2023年8月29日 · Sun et al. show that the top neurodevelopmental disorder risk factor POGZ is required to suppress retrotransposable elements in embryonic stem cells and during ESC differentiation toward a neural fate. The findings provide insights into understanding the disease mechanisms caused by POGZ dysfunction.