2024年12月25日 · POGZ (Pogo Transposable Element Derived With ZNF Domain) is a Protein Coding gene. Diseases associated with POGZ include White-Sutton Syndrome and Nail Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD1.

2020年2月26日 · Pogo transposable element derived with ZNF domain (POGZ) has been identified as one of the most recurrently de novo mutated genes in patients with neurodevelopmental disorders (NDDs), including...

2020年11月17日 · We demonstrate that Pogz deficient mice show microcephaly, growth impairment, increased sociability, learning and motor deficits, mimicking several of the human symptoms. At the molecular level,...

2023年8月29日 · Sun et al. show that the top neurodevelopmental disorder risk factor POGZ is required to suppress retrotransposable elements in embryonic stem cells and during ESC differentiation toward a neural fate. The findings provide insights into understanding the disease mechanisms caused by POGZ dysfunction.

POGZ plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PMID:20562864). Heterozygous mutation of POGZ causes White-Sutton syndrome (PMID: 26739615). Expect a band approximately 155 kDa in size corresponding to POGZ by western blotting.

POGZ 是神经发育障碍和神经精神疾病患者中最经常发生突变的基因之一，包括引发精神分裂症、神经外胚层衍生的智力障碍和 自闭症谱系障碍 等疾病。 然而，由 POGZ 突变引起的 神经发育紊乱 的潜在病因仍然难以确定。 人们对其在胚胎干细胞（ESCs）、神经发育和疾病中的作用知之甚少。 近日， 中国科学院水生生物研究所 孙玉华 研究团队在医学Top期刊Molecular Autism 以“Autism-associated protein POGZ controls ESCs and ESC neural induction by association …

POGZ plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PMID:20562864). Heterozygous mutation of POGZ causes White-Sutton syndrome (PMID: 26739615). Expect a band approximately 155 kDa in size corresponding to POGZ by western blotting. Storage Storage:

By sequencing clones obtained from a size-fractionated human brain cDNA library, Seki et al. (1997) cloned POGZ, which they designated KIAA0461. The deduced protein contains 1,355 amino acids.

Pogz-de ficient mice show growth delay, smaller absolute brain and defects in embryonic and adult neurogenesis. To test for association between Pogz and different mouse phenotypes, we tested...

2021年12月7日 · We map POGZ bound loci in human and mouse and probe transcriptional and chromatin state phenotypes of Pogz−/− mice. We find POGZ primarily binds euchromatic regions of the genome and acts to promote transcription and chromatin accessibility at gene REs.