Pol (DNA polymerase) refers to a gene in retroviruses, or the protein produced by that gene. Products of pol include: Common to all retroviruses, this enzyme transcribes the viral RNA into double-stranded DNA. This enzyme integrates the DNA produced by reverse transcriptase into the host's genome.

Pol enzymes are important for HIV reverse transcription, integration, budding, and maturation. A major HIV gene that encodes the Pol polyprotein (a long protein chain). The Pol polyprotein is broken down into four HIV enzymes: reverse transcriptase (RT), protease, RNAse H, …

2024年5月9日 · An approach targeting CARD8 inflammasome activation combined with a ‘shock and kill’ scheme may be explored for an HIV cure trial. Because Pol is a highly conserved region of the HIV genome, it can be targeted by CRISPR-Cas technology and designed for HIV vaccine.

The Pol protein of human immunodeficiency virus type 1 (HIV-1) harbours the viral enzymes critical for viral replication; protease (PR), reverse transcriptase (RT), and integrase (IN).

HIV-1 DNA表达的调控之所以那么精密和复杂，除了因为克服阻碍的需要，还有一个更重要的原因，那就是HIV-1高效地利用了自己的遗传物质。 HIV-1的基因组是复杂的。 在前文给出的HIV-1基因组的结构图上，你能够找到多少位碱基的片段对应地编码着哪些蛋白质。 然而你会发现约6000-9000号碱基对应的片段竟然能够编码三四种截然不同的蛋白质，很多蛋白质的编码区有重叠。 事实上，这是由阅读方式的不同而引起的。 一条肽链有着其固定的阅读方式。 若错位一个碱基 …

Currently available viral genotyping methods are useful for viral quantification, but are inadequate for sequence profiling or comprehensive mutation detection in the variable regions of HIV polymerase (pol). A novel set of universal primers within pol, with consensus among a variety of HIV-1 subtypes, was developed.

2022年7月11日 · 美国索尔克研究所和罗格斯大学研究人员首次确定了艾滋病病毒（HIV）Pol蛋白的分子结构，这是一种在HIV复制后期或病毒自我传播并扩散到全身过程中起关键作用的蛋白质，确定分子的结构有助于回答长期以来关于蛋白质如何分解自身以推进复制过程的问题。

23 小时之前 · HIV-1 pol gene diversity reflected HIV-1 subtype C being the dominant subtype and the presence of potential unique recombinant forms. Evolutionary estimates indicated that these recombinants might have emerged during 2004–2005, with ancestry of their subtype B traced to be of United States of America (USA) origin. The drug resistance mutation ...

2012年8月13日 · 本课题主要运用phylip、treeview和clustalx等软件，对hiv-1的pol基因进行了序列相似性比较。 系统发育推断软件PHYLIP即是PhylogenyInferencePackage的缩写，共包括37个程序,按照所处理数据对象的不同可分为五类。

2016年7月11日 · 采集HIV－1阳性全血样本，使用巢式PCR扩增gag和pol基因部分区段，得到23份样本的PCR序列和相应样本的克隆序列gag基因为449份、pol基因为402份，基因分型为HIV－1B和B′亚型。