
POLR2A Gene - GeneCards | RPB1 Protein | RPB1 Antibody
2024年12月25日 · POLR2A (RNA Polymerase II Subunit A) is a Protein Coding gene. Diseases associated with POLR2A include Neurodevelopmental Disorder With Hypotonia And Variable Intellectual And Behavioral Abnormalities and Skull Base Meningioma.
POLR2A - Wikipedia
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity.
POLR2A RNA polymerase II subunit A [ (human)] - National …
Data suggest RNA polymerase II (POLR2A) is extensively modified on its unique C-terminal domain (CTD) by O-GlcNAc transferase (OGT); efficient O-GlcNAcylation requires a minimum of 20 heptad CTD repeats in POLR2A and more than half of NTD of OGT.
Germline mutation in POLR2A : a heterogeneous, multi-systemic …
2021年1月14日 · We report twelve individuals harboring putatively pathogenic de novo or inherited variants in POLR2A, detail their phenotypes, and map all known variants to the domain structure of POLR2A and crystal structure of RNA polymerase II.
RNA 聚合酶 II 亚基 A(POLR2A)基因 | MCE - MCE-生物活性 ...
该基因编码 RNA 聚合酶 II 的最大亚基,这种聚合酶负责在真核生物中合成信使 RNA。 该基因的产物包含一个由聚合酶活性所必需的七肽重复组成的羧基末端结构域。 这些重复包含丝氨酸和苏氨酸残基,它们在活跃转录的 RNA 聚合酶中被磷酸化。 此外,该亚基与其他几个聚合酶亚基结合形成聚合酶的 DNA 结合域,即 DNA 模板在其中转录成 RNA 的凹槽。 [RefSeq 提供,2008 年 7 月] This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for …
Precise targeting of POLR2A as a therapeutic strategy for ... - Nature
2019年2月25日 · Inhibiting POLR2A expression upon siRNA delivery represents a promising therapeutic strategy for triple negative breast cancers characterized by p53 inactivation.
De Novo Heterozygous POLR2A Variants Cause a …
The RNA polymerase II complex (pol II) is responsible for transcription of all ∼21,000 human protein-encoding genes. Here, we describe sixteen individuals harboring de novo heterozygous variants in POLR2A, encoding RPB1, the largest subunit of pol ...
POLR2A RNA polymerase II subunit A [ Homo sapiens (human) ]
2025年2月9日 · Knockdown of polymerase (RNA) II (DNA directed) polypeptide A (POLR2A, 220kDa) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1: PubMed
Entry - *180660 - POLYMERASE II, RNA, SUBUNIT A; POLR2A
DNA-dependent RNA polymerase II (EC 2.7.7.6), a complex multisubunit enzyme, is responsible for the transcription of protein-coding genes. It is composed of 10 to 14 subunits ranging in size from 220 to 10 kD. POLR2A encodes the 220-kD subunit.
RNA聚合酶Ⅱ催化亚基POLR2A自身表达调控及其在肿瘤中作用研 …
POLR2A是RNA聚合酶Ⅱ的关键催化亚基,在基因表达中具有不可替代的作用. POLR2A自身的表达调控对细胞中基因转录至关重要,且近年来研究表... 展开更多 RNA聚合酶Ⅱ转录真核生物基因组中所有的蛋白质编码基因和许多非编码RNA. POLR2A是RNA聚合酶Ⅱ的关键催化亚基,在基因表达中具有不可替代的作用. POLR2A自身的表达调控对细胞中基因转录至关重要,且近年来研究表明, POLR2A与肿瘤等多种疾病密切相关.本文从转录、pre-m RNA剪接、m RNA稳定性,以及蛋白 …