In organic chemistry, polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (>C=O, or its reduced forms) and …

Polyketides (PK) are natural products that display diverse functions with clinical applications. Polyketides are assembled by polyketide synthase (PKS) enzymes. PKS enzymes operate …

Polyketides represent a family of highly structurally diverse compounds, all produced via iterative decarboxylative condensations of starter and extender units, analogous to the biosynthesis of …

2021年3月16日 · The polyketides, a diverse family of highly oxygenated natural products, are characterized by the presence of many β-dihydroxy or β-hydroxycarbonyl consonant polar …

2020年7月17日 · Notable examples of polyketides include lovastatin (anticholesterol), doxorubicin (anticancer), ivermectin (antiparasitic), and erythromycin A (macrolide antibiotic).

Polyketides regroup a wide variety of chemical building blocks pending from SM pathways and present several biological activities (Gokulan et al. 2014; Ridley and Khosla 2009; Tsai and …

Polyketides, as the name implies, are synthesized from repetitive condensation reactions that link small carbon precursors (typically, 2- and 3-carbon acyl groups derived from coenzyme A …