Multiple cereblon genetic changes are associated with acquired ...
2021年1月14日 · Almost one-third of myeloma patients have genetic alterations in CRBN (IMiD binding protein) by the time they are refractory to POM. Genetic changes to CRBN are …
Multiple cereblon genetic changes are associated with acquired ...
2021年1月14日 · Cereblon (CRBN) is the essential binding protein of the widely used immunomodulatory drugs (IMiDs) and novel CRBN E3 ligase modulator drugs (CELMoDs) in …
Investigating the Functional Impact of CRBN Mutations on …
2023年11月2日 · Previous data suggests almost one third of myeloma patients acquire CRBN mutations by the time they are Pom refractory. Some events, including stop codons/frameshift …
Structural and biophysical comparisons of the pomalidomide
2023年12月12日 · To expand our understanding of the molecular basis for the interaction of SALL4 with cereblon, we performed biophysical and structural studies demonstrating that …
Immunomodulatory drugs activate NK cells via both Zap-70 and
2020年4月1日 · Multiple groups have shown that Thal, Len, and Pom directly bind to cereblon (CRBN), forming an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1), …
Ligand-mediated protein degradation reveals functional …
Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteosomal destruction by engaging the …
Mutations in CRBN and Other Cereblon Pathway Genes Are Only …
2020年11月5日 · Mutations present in the lenalidomide resistant (Len-R) and pomalidomide resistant (Pom-R) but not their relevant DMSO exposed control were considered. From recent …
Leveraging Ligand Affinity and Properties: Discovery of Novel …
2023年10月30日 · Immunomodulatory imide drugs (IMiDs) such as thalidomide, pomalidomide, and lenalidomide are the most common cereblon (CRBN) recruiters in proteolysis-targeting …
Cereblon (CRBN) is the essential binding protein of the widely used immunomodulatory drugs (IMiDs) and novel CRBN E3 ligase modulator drugs (CELMoDs) in myeloma, as well as …
Identification of a Cereblon-Independent Protein Degradation Pathway …
2015年12月3日 · Recent studies have shown that binding of immune modulatory drugs (IMiDs) R lenalidomide and pomalidomide (Pom) to the CRBN-CRL4 E3 ubiquitin ligase complex leads …