Roles of the Wnt effector POP-1/TCF in the C. elegans …
2010年4月15日 · The nuclear Wnt effector TCF/POP-1 plays a central role in specification of MS. Loss of maternal pop-1 function through the maternal-specific allele zu189 or by RNAi results …
Wnt signaling in C. elegans: New insights into the regulation of …
2007年1月1日 · In the nematode Caenorhabditis elegans, Wnt signaling controls developmental processes such as cell fate specification, cell migration, and cell polarity. C. elegans utilizes …
C. elegans POP-1/TCF functions in a canonical Wnt pathway that ... - PubMed
In the embryo, a novel Wnt pathway functions through a (beta)-catenin homolog, WRM-1, to downregulate the levels of POP-1/Tcf in the posterior daughter of the EMS blastomere. The …
POP-1 and Anterior–Posterior Fate Decisions in - Cell Press
1998年1月23日 · These studies show that the Wnt-like signaling pathway is required for generating or interpreting a/p polarity throughout the early C. elegans embryo and that POP-1 …
C. elegans POP-1/TCF functions in a canonical Wnt pathway that …
2001年2月15日 · In Caenorhabditis elegans, Wnt signaling pathways are important in controlling cell polarity and cell migrations. In the embryo, a novel Wnt pathway functions through a β …
C. elegans TCF protein, POP-1, converts from repressor to …
2005年9月15日 · Contrary to this model, we demonstrate here that POP-1 directly activates Wnt target genes in the endoderm precursor. Wnt converts POP-1 from a repressor to an activator, …
Roles of the Wnt effector POP-1/TCF in the C. elegans ... - PubMed
2010年4月15日 · Our results suggest that POP-1 is not critical for MS specification beyond repression of endoderm specification, and reveal that Wnt-modified POP-1 and END-1/3 …
C. elegans TCF protein, POP-1, converts from repressor to ... - PubMed
2005年9月15日 · Wnt converts POP-1 from a repressor to an activator, and this conversion requires that POP-1 nuclear levels be lowered in the endoderm precursor. We propose that …
Phosphorylation by the β-Catenin/MAPK Complex Promotes 14
2004年4月2日 · We show here that WRM-1 downregulates POP-1 by promoting its phosphorylation by the MAP kinase LIT-1 and subsequent nuclear export via a 14-3-3 protein, …
Dynamics of a Developmental Switch: Recursive Intracellular and ...
2002年8月1日 · POP-1, a Tcf/Lef factor, functions throughout Caenorhabditis elegans development as a Wnt-dependent reiterative switch to generate nonequivalent sister cells that …