2020年4月18日 · Urothelial carcinomas of the upper urinary tract (UTUCs) are rare, with poorer stage-for-stage prognosis than urothelial carcinomas of the urinary bladder. No international consensus exists on the benefit of adjuvant chemotherapy for patients with UTUCs after nephroureterectomy with curative intent.

2024年2月13日 · POUT was a phase III, randomized, open-label trial, including 261 patients with muscle-invasive or lymph node–positive, nonmetastatic upper tract urothelial cancer (UTUC) randomly assigned after radical nephroureterectomy to platinum-based chemotherapy (132) or surveillance (129).

2018年7月17日 · 要通过一个流对象打开一个文件，我们使用它的成员 函数 open ()： void open (const char * filename, openmode mode); 这里filename 是一个字符串，代表要打开的文件名，mode 是以下标志符的一个组合： 这些标识符可以被组合使用，中间以”或”操作符 (|)间隔。 例如，如果我们想要以二进制方式打开文件"example.bin" 来写入一些数据，我们可以通过以下方式调用成员函数open（）来实现： ofstream, ifstream 和 fstream所有这些类的成员函数open 都包含 …

2021年3月2日 · Here we present results of a pre-planned analysis updating the primary endpoint and reporting key secondary endpoints including overall survival.

2024年2月22日 · In 2020, adjuvant platinum-based chemotherapy became the standard of care for patients with muscle-invasive or locally advanced upper tract urothelial carcinoma of the ureter or renal pelvis (UTUC)...

2021年2月16日 · POUT研究是一项针对UTUC患者术后接受辅助化疗与观察对比的多中心随机对照Ⅲ期临床试验，该研究旨在评估基于铂类药物的全身化疗对UTUC患者的临床获益。

The POUT trial is the largest randomized control trial published, evaluating the efficacy of gemcitabine–platinum-based chemotherapy in UTUC, and it provides Level I support for ACT in muscle-invasive or node-positive disease.

2021年2月13日 · The primary endpoint was disease free survival and secondary endpoints included metastasis free survival, overall survival, toxicity, and patient-reported quality of life. The trial was closed to recruitment early on the advice of the independent data monitoring committee due to evidence of efficacy. The trial schema for POUT is as follows:

昨日，英国伦敦癌症研究所在《柳叶刀肿瘤》杂志上发表新研究，研究人员进行了全世界针对肾癌进行的最大规模试验——POUT试验，发现化学疗法使手术后复发罕见形式的肾癌的风险降低了一半。

The POUT (Peri-Operative chemotherapy versus sUrveillance in upper Tract urothelial cancer) trial aimed to assess the eficacy of systemic platinum-based chemotherapy in patients with UTUCs.