Patients with Pneumocystis pneumonia (PCP) typically present with fever, nonproductive cough, dyspnea, and hypoxemia with diffuse bilateral ground-glass opacities on chest imaging. 1 PCP can be prevented by reducing immunosuppression and with chemoprophylaxis.

耶氏肺孢子菌是免疫受损患者肺炎的常见病因，尤其是人免疫缺陷病毒（HIV）感染者和接受全身糖皮质激素治疗的患者。 症状包括发热、呼吸困难和干咳。 诊断需在诱导痰或支气管刷检标本中找到病原体。 治疗方法是使用抗生素，通常 甲氧苄啶/磺胺甲恶唑或氨苯砜/甲氧苄氨嘧啶，克林霉素/伯氨喹，阿托伐醌，或喷他脒。 PaO2 患者 < 70 毫米汞柱或血氧饱和度 < 92% 接受全身性皮质类固醇治疗。 若治疗及时，通常预后良好。 (参见肺炎概述 和 免疫缺陷患者肺炎.) …

2023年1月21日 · Pneumocystis carinii pneumonia (PCP), now referred to as Pneumocystis jirovecii pneumonia, is a fungal infection that most commonly affects the immunocompromised and, in some cases, can be severely life-threatening.

2024年5月23日 · 近年来，耶氏肺孢子菌肺炎（Pneumocystis jiroveci pneumonia，PJP）的发病率呈明显上升趋势。 据统计，2012—2017年，美国医保住院约1亿人次，其中免疫抑制宿主（immune compromised host，ICH）人数约为700万，包括HIV感染/AIDS，恶性血液系统肿瘤、实体肿瘤、器官移植、风湿科疾病、免疫抑制药物及2周以上激素治疗的患者[1]。PJP数量的增加与ICH的大量增加、诊断技术的进步（如ICU-BAL、PCR、mNGS）密切相关。在中国、法国 …

2025年3月10日 · What is Pneumocystis jiroveci pneumonia (PJP)? PJP is a lung infection caused by the Pneumocystis jiroveci fungus. PJP is most often seen in people with a weak immune system. PJP is an opportunistic infection. This means that when your immune system is not working well, it cannot fight off the fungus. What causes PJP?

2024年9月18日 · 耶氏肺孢子菌肺炎（PJP或PCP）的系统抗微生物治疗应基于高危病例的临床症状和体征、典型放射学表现及实验室检查。 通过支气管肺泡灌洗来寻找诊断依据不应拖延相应的治疗。 血液恶性肿瘤患者伴发的PCP多数病情严重，治疗时需静脉注射药物，首选大剂量磺胺甲噁唑/甲氧苄啶；不能耐受此药物者可应用伯氨喹+克林霉素。 治疗1周后即评估疗效，治疗无效的病例则可再行肺部CT扫描和支气管肺泡灌洗，以确认是否存在继发感染或合并其他病原体的感染 …

We aim to review and summarize the etiology, epidemiology, clinical presentation, diagnosis, and management of Pneumocystis jirovecii pneumonia in HIV, and non-HIV patients. HIV patients usually have mild-to-severe symptoms, while non-HIV patients present with a …

肺孢子菌肺炎 (Pneumocystis pneumonia, PCP)是可能危及生命的感染，发生于免疫功能受损者。 感染人类的肺孢子菌种命名已由卡氏肺孢子菌 (Pneumocystis carinii)改为耶氏肺孢子菌 (Pneumocystis jirovecii)，以此来与感染大鼠的肺孢子菌种相区分。 人们认为，大多数哺乳动物至少可感染一种肺孢子菌 (Pneumocystis) [1]。 CD4计数低的HIV感染者发生PCP的风险最高。

Symptomatic infection with Pneumocystis jirovecii is extremely rare in healthy people. However, in immunocompromised infants and children, P jirovecii causes a respiratory illness characterized by dyspnea, tachypnea, significant hypoxemia, nonproductive cough, chills, fatigue, and fever.

2020年6月29日 · PJP (previously known as Pneumocystis Carinii Pneumonia) presents differently, depending on whether the patient is HIV-negative or HIV-positive [HIV (-)PJP versus HIV (+)PJP]. HIV causes PJP pneumonia to present more indolently, with a higher burden of organisms. This makes HIV (+)PJP somewhat easier to diagnose and treat.