B细胞在骨髓中的发育经历了祖B细胞（pro B cell）、前B细胞（pre B cell）、未成熟B细胞（immature B cell）和成熟B细胞（mature B cell）等几个阶段。

Large pre-B cell是成功表达重链并通过B细胞第一个检查点的细胞。每个large pre-B细胞都会经历几轮细胞分裂，产生大约100个含相同μ链的细胞（small pre-B cell）。此时细胞不再表达pre …

B细胞的分化过程主要可分为前B细胞（Pre-B cell）、不成熟B细胞(immature B cell)、成熟B细胞(mature B cell)、活化B细胞(activated B cell)和浆细胞(plasma cell)五个阶段。 B细胞分化的各 …

Downstream of the pre-BCR, SYK (spleen tyrosine kinase) has a central role in the activation of pathways that regulate the proliferation and differentiation of pre-B cells. In the context of...

前B细胞（pre-B cell）是2014年公布的组织学与胚胎学名词。 由祖B细胞分化而来，约占成人骨髓有核细胞的5%。 其已完成重链基因重排，但轻链基因重排尚未开始，形态较大，不表达膜免 …

Following proliferation, small pre-B cells (no longer dividing) undergo V-J joining on one L chain chromosome. Once L chain has been successfully synthesized, it is expressed with m chain …

The pre-B-cell receptor (pre-BCR) is composed of two immunoglobulin mu heavy chains and two surrogate light chains, which associate with the signaling molecules Igalpha and Igbeta …

2022年8月11日 · In positive selection, your developing B cells are selected for survival if the pre-B receptor binds its ligand successfully. What this means is that those B cells have receptors …

2018年11月14日 · When pre-B cells leave the cell cycle and become small pre-B cells, light chain genes are rearranged that encode for a light chain protein forming a B cell receptor with the …

2018年11月5日 · Pre-B cells represent the immature stage of the B cell lineage and express genes for the pre-B cell receptor (preBCR). PreBCR consists of lambda 5 and VpreB and its …