
B细胞的发育过程 - 知乎 - 知乎专栏
B细胞在骨髓中的发育经历了祖B细胞(pro B cell)、前B细胞(pre B cell)、未成熟B细胞(immature B cell)和成熟B细胞(mature B cell)等几个阶段。
体液免疫(二):B细胞的前世今生(上) - 知乎专栏
Large pre-B cell是成功表达重链并通过B细胞第一个检查点的细胞。每个large pre-B细胞都会经历几轮细胞分裂,产生大约100个含相同μ链的细胞(small pre-B cell)。此时细胞不再表达pre B-cell receptor。RAG基因再次被激活,开始下一轮轻链重组。
分泌抗体B细胞筛选方案 - 知乎 - 知乎专栏
B细胞的分化过程主要可分为前B细胞(Pre-B cell)、不成熟B细胞(immature B cell)、成熟B细胞(mature B cell)、活化B细胞(activated B cell)和浆细胞(plasma cell)五个阶段。 B细胞分化的各个阶段可以通过评估不同…
Regulation of B-cell proliferation and differentiation by pre-B-cell ...
Downstream of the pre-BCR, SYK (spleen tyrosine kinase) has a central role in the activation of pathways that regulate the proliferation and differentiation of pre-B cells. In the context of...
前B细胞 - 百度百科
前B细胞(pre-B cell)是2014年公布的组织学与胚胎学名词。 由祖B细胞分化而来,约占成人骨髓有核细胞的5%。 其已完成重链基因重排,但轻链基因重排尚未开始,形态较大,不表达膜免疫球蛋白,可表达CD19分子。 由祖B细胞分化而来的细胞。 能检出的最早标志是免疫球蛋白重链基因重排,但无轻链基因重排,因此也无膜免疫球蛋白表达。 《组织学与胚胎学名词》。 前B细胞(pre-B cell)是2014年公布的组织学与胚胎学名词。
B Cell Development - Northern Arizona University
Following proliferation, small pre-B cells (no longer dividing) undergo V-J joining on one L chain chromosome. Once L chain has been successfully synthesized, it is expressed with m chain on the cell membrane and the cell is called an immature B cell. Immature B cells are very sensitive to antigen binding, so if they bind self antigen in the ...
The pre-B-cell receptor - PubMed
The pre-B-cell receptor (pre-BCR) is composed of two immunoglobulin mu heavy chains and two surrogate light chains, which associate with the signaling molecules Igalpha and Igbeta (Igalpha/beta). The production of a functional pre-BCR is the first checkpoint in the current model of B-cell developmen …
B cell development stages Explained in a Simple Way
2022年8月11日 · In positive selection, your developing B cells are selected for survival if the pre-B receptor binds its ligand successfully. What this means is that those B cells have receptors that can recognize and respond to foreign antigens.
The Role of the Pre-B Cell Receptor in B Cell Development, …
2018年11月14日 · When pre-B cells leave the cell cycle and become small pre-B cells, light chain genes are rearranged that encode for a light chain protein forming a B cell receptor with the selected μH chain. Five cell divisions at the pre-B cell stage are depicted, leading to 32-fold higher output of B cells in wild type vs. SL knockout mice.
Signaling Pathway for the Development of Pre-B Cells
2018年11月5日 · Pre-B cells represent the immature stage of the B cell lineage and express genes for the pre-B cell receptor (preBCR). PreBCR consists of lambda 5 and VpreB and its expression elicits a rearrangement of the immunoglobulin heavy chain prior to rearrangement of the immunoglobulin light chain.
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