B细胞在骨髓中的发育经历了祖B细胞（pro B cell）、前B细胞（pre B cell）、未成熟B细胞（immature B cell）和成熟B细胞（mature B cell）等几个阶段。

Large pre-B cell是成功表达重链并通过B细胞第一个检查点的细胞。每个large pre-B细胞都会经历几轮细胞分裂，产生大约100个含相同μ链的细胞（small pre-B cell）。此时细胞不再表达pre B-cell receptor。RAG基因再次被激活，开始下一轮轻链重组。

B细胞的分化过程主要可分为前B细胞（Pre-B cell）、不成熟B细胞(immature B cell)、成熟B细胞(mature B cell)、活化B细胞(activated B cell)和浆细胞(plasma cell)五个阶段。 B细胞分化的各个阶段可以通过评估不同…

Downstream of the pre-BCR, SYK (spleen tyrosine kinase) has a central role in the activation of pathways that regulate the proliferation and differentiation of pre-B cells. In the context of...

前B细胞（pre-B cell）是2014年公布的组织学与胚胎学名词。 由祖B细胞分化而来，约占成人骨髓有核细胞的5%。 其已完成重链基因重排，但轻链基因重排尚未开始，形态较大，不表达膜免疫球蛋白，可表达CD19分子。 由祖B细胞分化而来的细胞。 能检出的最早标志是免疫球蛋白重链基因重排，但无轻链基因重排，因此也无膜免疫球蛋白表达。 《组织学与胚胎学名词》。 前B细胞（pre-B cell）是2014年公布的组织学与胚胎学名词。

Following proliferation, small pre-B cells (no longer dividing) undergo V-J joining on one L chain chromosome. Once L chain has been successfully synthesized, it is expressed with m chain on the cell membrane and the cell is called an immature B cell. Immature B cells are very sensitive to antigen binding, so if they bind self antigen in the ...

The pre-B-cell receptor (pre-BCR) is composed of two immunoglobulin mu heavy chains and two surrogate light chains, which associate with the signaling molecules Igalpha and Igbeta (Igalpha/beta). The production of a functional pre-BCR is the first checkpoint in the current model of B-cell developmen …

2022年8月11日 · In positive selection, your developing B cells are selected for survival if the pre-B receptor binds its ligand successfully. What this means is that those B cells have receptors that can recognize and respond to foreign antigens.

2018年11月14日 · When pre-B cells leave the cell cycle and become small pre-B cells, light chain genes are rearranged that encode for a light chain protein forming a B cell receptor with the selected μH chain. Five cell divisions at the pre-B cell stage are depicted, leading to 32-fold higher output of B cells in wild type vs. SL knockout mice.

2018年11月5日 · Pre-B cells represent the immature stage of the B cell lineage and express genes for the pre-B cell receptor (preBCR). PreBCR consists of lambda 5 and VpreB and its expression elicits a rearrangement of the immunoglobulin heavy chain prior to rearrangement of the immunoglobulin light chain.