Binding of Hepatitis B Virus Pre-S1 Domain-Derived Synthetic
2022年1月7日 · (1) Background: The myristoylated pre-S1 peptide (Myr47) synthesized to mimic pre-S1 domain (2-48) in large (L) surface protein of hepatitis B virus (HBV) prevents HBV …
NTCP转运体在药物研发中的应用简介 - 知乎 - 知乎专栏
也有科学家发现了一种低聚黄酮原花青素（PAC）及其类似物作为一种新的进入抑制剂，直接靶向HBV大包膜蛋白的pre-S1结构域，从而阻止其与NTCP的附着。 通过直接靶向HBV颗粒，损害 …
The Culprit Behind HBV-Infected Hepatocytes: NTCP - PubMed
2024年10月28日 · In this review, we will examine the regulatory mechanisms governing HBV pre-S1 binding to liver membrane NTCP, the role of NTCP in HBV internalization, and the …
The Innovation｜解密乙肝病毒受体的结构 - 腾讯网
2022年8月8日 · Goutam等人利用荧光标记HBV Pre-S1多肽，分析NTCP“向内开口”构象（NTCP-Nb87）与“向外开口”构象（NTCP-Nb91）之间的区别，提出Pre-S1更倾向于结合NTCP ...
Structural basis of hepatitis B virus receptor binding
2024年1月17日 · Myristoylated preS1 domain of the HBV large surface protein binds to the host receptor sodium-taurocholate cotransporting polypeptide (NTCP), a hepatocellular bile acid …
Targeting NTCP for liver disease treatment: A promising strategy
2024年9月1日 · PreS1, a binding peptide of the high-affinity receptor HBV, is attached to the binding domain of NTCP. The tunnel formed by TM1, TM6, TM8b, and TM9 may be …
HBV life cycle is restricted in mouse hepatocytes expressing human NTCP
2014年2月10日 · NTCP can specifically bind to the myristoylated N-terminal of pre-S1, but is absent from the surface of commonly used hepatocyte cell lines, such as HepG2 and Huh7. 13...
Sodium taurocholate cotransporting polypeptide is a functional …
2012年11月13日 · Here, by using near zero distance photo-cross-linking and tandem affinity purification, we revealed that the receptor-binding region of pre-S1 specifically interacts with …
The Culprit Behind HBV-Infected Hepatocytes: NTCP - Dove …
2024年5月27日 · In this review, we will examine the regulatory mechanisms governing HBV pre-S1 binding to liver membrane NTCP, the role of NTCP in HBV internalization, and the …
Sodium taurocholate cotransporting polypeptide is a functional …
2012年11月13日 · In this study, by employing a unique approach of tandem affinity purification combined with MS analysis against a Tupaia hepatocyte proteome database established by …