2021年8月13日 · We review different models of adaptive behavior to demonstrate how their components map onto this unifying framework and specific PFC regions. Finally, we discuss how our framework may help to...

Here, computational models are shown to overcome these theoretical shortcomings by providing more precise accounts, predictions, and simulations of PFC function at the neuronal and behavioral levels. Two approaches have been developed in neurobiology and cognitive neuroscience, respectively.

2024年12月18日 · The complex neural activity of prefrontal cortex (PFC) is a hallmark of cognitive processes. How these rich dynamics emerge and support neural computations is largely unknown. Here, we infer mechanisms underlying the context-dependent integration of sensory inputs by fitting dynamical models to PFC population responses of behaving monkeys.

2024年8月29日 · We conducted a randomised, double-blinded, sham-controlled brain stimulation study using transcranial direct current stimulation (tDCS) in young adults spanning over three weeks to assess the role...

2016年5月20日 · We presented a model of the prefrontal cortex which is entirely defined by electrophysiological and anatomical data, and is capable of reproducing a wide range of in vivo statistics, including properties of single spike trains and pairwise correlations, the power spectrum of the local field potential and the variability of the membrane potential.

Here, using functional MRI, we demonstrate a mechanism by which the ventromedial prefrontal cortex supports such episodic simulations, and thereby contributes to affective foresight: This region supports processes that (i) integrate knowledge related to the elements that constitute an episode and (ii) represent the episode’s emergent affective q...

2024年6月13日 · In this study, we present a biophysical computational model encompassing three crucial regions, including the dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, and ventromedial prefrontal cortex.

2 天之前 · Certain regions in the orbitofrontal (OFC) and prefrontal-cortex (PFC) show fast alignment times compared with other regions having a similar distance from the visual network. ... For simulation ...

2019年7月15日 · We use a biologically motivated computational framework known as ‘reservoir computing’ to model prefrontal cortex (PFC) in sequence learning, in which large pools of prewired neural elements process information dynamically through reverberations.

This study examines a key role of ventromedial prefrontal cortex (vmPFC) in mediating simulations of future affective episodes and, thereby, in contributing to affective foresight. The vmPFC is part of a network that is consistently engaged during the construction of potential future scenarios and during the recollection of past events ( 10 , 11 ).