2007年8月1日 · PrfA activates transcription by binding as a dimer to a palindromic promoter element of canonical sequence tTAACanntGTtAa, with seven invariant nucleotides (in …

2024年12月1日 · Positive Regulatory Factor A (PrfA) is a well-studied transcription factor in L. monocytogenes that is responsible for activating a plethora of virulence factors. Targeting …

荧光聚合酶链式反应检测EGDe-ΔprfA的主要毒力基因表达，结果显示plcA、plcB毒力基因的表达量分别上升至原来 的2.5 倍和2 倍，inlA、inlB、inlC、actA、vip等均呈下降趋势，prfA基因表达 …

Hainzl et al. structurally explain the mechanism of promiscuous (sequence-independent) inhibition of Listeria virulence activator PrfA by environmental oligopeptides. Parallel and antiparallel β …

单核细胞增生李斯特菌是能够引起严重人类感染的革兰氏阳性病原体。 它的主要毒力调节剂是转录激活剂PrfA，它是Crp / Fnr转录调节剂家族的成员。 要建立成功的单核细胞增生李斯特氏菌感 …

2019年10月16日 · Here we report the crystal structure of PrfA with a small molecule inhibitor occupying the coactivator site at 2.0 Å resolution. Using molecular imaging and infection …

Most virulence genes of Listeria monocytogenes are activated by the transcriptional regulator PrfA. Previous studies have shown that environmental parameters, such as temperature, pH, …

2020年11月24日 · 在单核细胞增生性李斯特菌中，关键转录因子PrfA的表达是由RNAT在其5'UTR中介导的。 PrfA充当单核细胞增生李斯特氏菌毒力的主要调节剂，控制许多毒力因子的 …

Two transcriptional regulators, the alternative sigma factor B (σ B) and the Positive Regulatory Factor A (PrfA), are key contributors to the transcriptomic responses that enable bacterial …

2023年12月10日 · Positive Regulatory Factor A (PrfA) is a well-studied transcriptional factor in Listeria monocytogenes that is responsible for activating a plethora of virulence...