2024年12月25日 · PRKAA1 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PRKAA1 include Mitochondrial Disease and Wolff-Parkinson-White Syndrome. Among its related pathways are Gene expression (Transcription) and Transmission across Chemical Synapses.

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene. [5][6] The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits.

该基因编码的蛋白质属于 ser/thr 蛋白激酶家族。 它是 5'-prime-AMP 活化蛋白激酶 (AMPK) 的催化亚基。 AMPK 是一种保存在所有真核细胞中的细胞能量感受器。 AMPK 的激酶活性由增加细胞 AMP/ATP 比率的刺激物激活。 AMPK 通过磷酸化调节许多关键代谢酶的活性。 它通过关闭消耗 ATP 的生物合成途径来保护细胞免受导致 ATP 耗尽的压力。 已经观察到编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene belongs to the …

2018年11月7日 · Selective deletion of endothelial Prkaa1, coding for protein kinase AMP-activated catalytic subunit alpha1, reduces glycolysis, compromises endothelial cell proliferation, and accelerates the...

AMP-activated protein kinase is a key regulator of obesity-associated factors. PRKAA1, stabilized by FTO in an m6A-YTHDF2-dependent manner, promotes cell proliferation and glycolysis of gastric cancer by regulating the redox balance.

In summary, we revealed a novel mechanism for crizotinib-induced cardiotoxicity, wherein the crizotinib-impaired autophagy process causes cardiomyocyte death and cardiac injury by inhibiting the degradation of MET protein, demonstrated a new function of impeded autophagosome-lysosome fusion in drugs-induced cardiotoxicity, pointed out the ...

2016年6月16日 · Here, we demonstrate that PRKAA (a catalytic subunit of AMPK) is activated in response to HBV-induced oxidative stress, which in turn decreases the production of HBV. Mechanistic studies reveal that the autophagy machinery is associated with the inhibitory effect of PRKAA/AMPK on HBV production.

2017年1月13日 · Here, we report that PRKAA regulated mitochondrial fission via the autophagy-dependent degradation of DNM1L (dynamin 1-like). Deletion of Prkaa1 /AMPKα1 or Prkaa2 /AMPKα2 resulted in defective autophagy, DNM1L accumulation, and aberrant mitochondrial fragmentation in the mouse aortic endothelium.

2015年1月28日 · PRKAA has been shown to enhance autophagy formation at least by 2 mechanisms: a direct activation of the key autophagy kinase ULK1 through phosphorylation at S317, which is involved in nucleation of the phagophore membrane 11 and an indirect activation of autophagy through inhibition of MTORC1 signaling, which is known as a suppressor of ...

Here, we demonstrate that PRKAA (a catalytic subunit of AMPK) is activated in response to HBV-induced oxidative stress, which in turn decreases the production of HBV. Mechanistic studies reveal that the autophagy machinery is associated with the inhibitory effect of PRKAA/AMPK on HBV production.