2024年12月25日 · PRKAA1 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PRKAA1 include Mitochondrial Disease and Wolff-Parkinson-White Syndrome.Among its related pathways are Gene expression (Transcription) and Transmission across Chemical Synapses.Gene Ontology (GO) annotations related to this gene include transferase activity, transferring ...

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. [5] [6]The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase ().AMPK is a cellular energy sensor conserved in all eukaryotic cells.

PRKAA1 could combine with miR-497-5p, and LINC00473 knockdown or miR-497-5p overexpression downregulated the mRNA and protein expression of PRKAA1. Together these results indicate that endothelial PKA activity mediates a critical switch from active sprouting to quiescence in part through phosphorylation of ATG16L1, which in turn reduces ...

蛋白激酶 AMP 激活的催化亚基 alpha 1： 该基因编码的蛋白质属于 ser/thr 蛋白激酶家族。它是 5'-prime-AMP 活化蛋白激酶 (AMPK) 的催化亚基。 AMPK 是一种保存在所有真核细胞中的细胞能量感受器。 AMPK 的激酶活性由增加细胞 AMP/ATP 比率的刺激物激活。 AMPK 通过磷酸化调节许多关键代谢酶的活性。

2018年11月7日 · Increased expression of Prkaa1/AMPK in atheroprone ECs. To assess the functional role of endothelial Prkaa1 in atherosclerosis, we first examined the levels of Prkaa1 and its phosphorylated form ...

2025年2月11日 · PRKAA1/AMPK activity does not require autophagy in a mouse model; Ampkalpha1 stimulates ubiquitination of the gap junction protein Cx43, thereby contributing to gap junction remodeling following pressure overload. AMPK directly relaxes vascular smooth muscle cell by a decrease of [Ca(2+)]i. This is achieved by calcium sequestration via SERCA ...

2018年11月7日 · Selective deletion of endothelial Prkaa1, coding for protein kinase AMP-activated catalytic subunit alpha1, reduces glycolysis, compromises endothelial cell proliferation, and accelerates the formation of atherosclerotic lesions in hyperlipidemic mice. Rescue of the impaired glycolysis in Prkaa1-deficient endothelial cells through Slc2a1 ...

prkaa1（蛋白激酶amp激活的催化亚基α1）是amp激活蛋白激酶（ampk）的催化亚基，在磷酸化调节细胞能量代谢中起关键作用，并且发现prkaa1的遗传变异是与胃癌风险有关。然而，尚未完全了解prkaa1对胃癌肿瘤发生，特别是增殖和凋亡的作用及其潜在的分子机制。我们的数据表明，与其他胃癌细胞相比 ...

2024年12月10日 · Go to Variation Viewer for PRKAA1 variants; Summary. The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that ...

PRKAA1 - Protein Kinase AMP-activated Catalytic Subunit Alpha 1. 别称: AMPK. AMPKa1. AMPK alpha 1.