2024年12月25日 · PRKAA2 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 2) is a Protein Coding gene. Diseases associated with PRKAA2 include Ischemia and Peutz-Jeghers Syndrome. Among its related pathways are Selective autophagy and Gene expression (Transcription).

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene. [5] [6]

AMPK 是一种异源三聚体，由一个 α 催化亚基以及非催化 β 和 γ 亚基组成。 AMPK 是一种重要的能量感应酶，可监测细胞能量状态。 响应细胞代谢应激， AMPK 被激活，从而使乙酰辅酶 A 羧化酶 (ACC) 和 β-羟基β-甲基戊二酰辅酶 A 还原酶 (HMGCR) 磷酸化和失活，这些酶是参与调节脂肪酸和胆固醇从头生物合成的关键酶.对小鼠对应物的研究表明，这种催化亚基可以控制全身胰岛素敏感性，并且是在缺血期间维持心肌能量稳态所必需的。 [RefSeq 提供，2008 年 7 月] The …

PRKAA2 is a prognostic marker in Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma

2025年2月8日 · Clinical resource with information about PRKAA2, The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes., and available tests.

2024年1月6日 · PRKAA2 identifies the low-energy charge of the cell that causes alterations in cellular metabolism. PRKAA2 targets the TSC complex subunit 2 and regulatory-associated protein of MTOR complex 1 (RAPTOR), a critical regulator of MTOR activity, through phosphorylation. RAPTOR phosphorylation inhibits MTOR activity [27, 84, 85].

PRKAA2 gene influences insulin resistance and susceptibility to type 2 diabetes in the Japanese population. Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase.

2024年12月25日 · This study aims to identify the role of key ferroptosis-related gene (protein kinase AMP-activated catalytic subunit alpha 2, PRKAA2) and explore new directions for the diagnosis and treatment of NSCLC. The PRKAA2 expression and its influence on survival were analyzed in multiple public databases (TCGA, TIMER2.0, and GEPIA).

2025年2月11日 · Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including regulation of autophagy; regulation of organelle organization; and regulation of protein modification process.

探讨腺苷酸活化蛋白激酶亚基α2 (protein kinase AMP-activated catalytic subunit alpha 2，Prkaa2）与核糖体蛋白S6激酶A1 （ribosomal protein S6 kinase A1，Rps6ka1）的关系及Prkaa2对转化生长因子β1 （transforming growth factor-β，TGF-β1）诱导的肾小管上皮细胞纤维化的影响。 用重组蛋白TGF-β1诱导NRK-52e细胞制备纤维化的细胞模型。